PARP-1 Inhibition Rescues Short Lifespan in Hyperglycemic C PARP-1 Inhibition Rescues Short Lifespan in Hyperglycemic C. Elegans And Improves GLP-1 Secretion in Human Cells Xia Qianghua 1 ;Lu Sumei 1 ;Ostrovsky Julian 1 ;E. McCormack Shana 2, 3, 4 ;J. Falk Marni 1, 3 ;F. A. Grant Struan 1, 2, 3, 4 ; 1 Division of Human Genetics, The Children#cod#x02019;s Hospital of Philadelphia, Philadelphia, PA 19104, USA ; 2 Division of Endocrinology and Diabetes, The Children#cod#x02019;s Hospital of Philadelphia, Philadelphia, PA 19104, USA ; 3 Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA ; 4 Institute of Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA ; Figure 5. Olaparib enhances promotes GLP-1 secretion in NCI-H716 cells. Cells were stimulated for 30 minutes with or without 16 mM glucose. GLP-1 was measured by ELISA. Bars represent the mean of three independent experiments normalized to the control. Error bars indicate standard deviation. Statistical analyses were performed by two-tailed Student#cod#x00027;s t-test and significance is denoted by asterisks where #cod#x0002A; P #cod#x0003C;0.05. null,null,0(0),null-null. Doi:10.14336/AD.2017.0230