Table 1. Genes with strong association for celiac disease

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Table 1. Genes with strong association for celiac disease Gene name Gene location Protein function RGS1 1q31 a member of the regulator of G-protein signalling family IL1R1 2q12 a receptor for interleukin-1 alpha IL18R1 a cytokine receptor that belongs to the interleukin 1 receptor Family and binds interleukin 18 IL18RAP a subunit of the receptor for interleukin 18 SLC9A4 solute carrier CCR1 3p21 a member of the beta chemokine receptor family CCR3 a receptor for C-C type chemokines IL12A 3q25 a subunit of a cytokine that acts on T and natural killer cells SCHIP1 schwannomin-interacting protein 1 LPP 3q28 a member of a subfamily of LIM domain proteins IL2 4q27 a secreted cytokine important for the proliferation of T and B lymphocytes IL21 a member of a family of cytokines with immunoregulatory activity TAGAP 6q25 a function as a Rho GTPase-activating protein SH2B3 / LNK 12q24 a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis ATXN2 defects in the gene is the cause of spinocerebellar ataxia type 2 Pavel Procházka et al. Genetic Aspects of Celiac Disease in Association with Pancreatic Tumors. International Journal of Celiac Disease, 2014, Vol. 2, No. 3, 93-96. doi:10.12691/ijcd-2-3-6 © The Author(s) 2014. Published by Science and Education Publishing.