Effect of storage time on metabolite profile and alpha-glucosidase inhibitory activity of Cosmos caudatus leaves – GCMS based metabolomics approach Neda.

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Effect of storage time on metabolite profile and alpha-glucosidase inhibitory activity of Cosmos caudatus leaves – GCMS based metabolomics approach Neda Javadi, Faridah Abas, Ahmed Mediani, Azizah Abd Hamid, Alfi Khatib, Sanimah Simoh, Khozirah Shaari Journal of Food and Drug Analysis Volume 23, Issue 3, Pages 433-441 (September 2015) DOI: 10.1016/j.jfda.2015.01.005 Copyright © 2015 Terms and Conditions

Fig. 1 Alpha glucosidase inhibitory activity and IC50 value of Cosmos caudatus samples at different storage times. Data are presented as mean ± SD, n = 7. Data in each column with different subscript letters are significantly different (p < 0.05). Journal of Food and Drug Analysis 2015 23, 433-441DOI: (10.1016/j.jfda.2015.01.005) Copyright © 2015 Terms and Conditions

Fig. 2 Gas chromatography-mass spectrometry (GC-MS) total ion chromatogram of Cosmos caudatus (A) in fresh sample and (B) after 12 hours of storage. 1 = catechin; 2 = α-tocopherol; 3 = cyclohexen-1-carboxylic acid; 4 = benzoic acid; 5 = myo-inositol; 6 = stigmasterol; 7 = lycopene; 8 = sucrose; 9 = α-d-galactopyranose; 10 = turanose. Journal of Food and Drug Analysis 2015 23, 433-441DOI: (10.1016/j.jfda.2015.01.005) Copyright © 2015 Terms and Conditions

Fig. 3 Orthogonal partial least squares (OPLS) score (A) and loading column plots (B) at different storage times (0 hours, 2 hours, 4 hours, 6 hours, 8 hours, 10 hours, and 12 hours) of Cosmos caudatus extracts. 1 = catechin; 2 = α-tocopherol; 3 = cyclohexen-1-carboxylic acid; 4 = benzoic acid; 5 = myo-inositol; 6 = stigmasterol; 7 = lycopene; 8 = sucrose; 9 = α-d-galactopyranose; 10 = turanose. Journal of Food and Drug Analysis 2015 23, 433-441DOI: (10.1016/j.jfda.2015.01.005) Copyright © 2015 Terms and Conditions

Fig. 4 Prediction versus observation of IC50 values from all samples. The R² of the regression line indicates the goodness of fit between experimental observations and predicted model. R² in this correlation was 0.935898. Journal of Food and Drug Analysis 2015 23, 433-441DOI: (10.1016/j.jfda.2015.01.005) Copyright © 2015 Terms and Conditions