From: Fundus Camera-Delivered Light-Induced Retinal Degeneration in Mice With the RPE65 Leu450Met Variant is Associated With Oxidative Stress and Apoptosis.

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Invest. Ophthalmol. Vis. Sci ;57(11): doi: /iovs Figure Legend:

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From: Fundus Camera-Delivered Light-Induced Retinal Degeneration in Mice With the RPE65 Leu450Met Variant is Associated With Oxidative Stress and Apoptosis Invest. Ophthalmol. Vis. Sci.. 2016;57(13):5558-5567. doi:10.1167/iovs.16-19965 Figure Legend: Retinal thinning and apoptosis after fundus camera-delivered light-induced retinal degeneration protocols. Histology images (A–C) and TUNEL staining (E–G) in C57BL/6J eyes that were either naive (A, E), exposed to the “Light-only” FCD-LIRD protocol (30 minutes of 125 K lux of white light; [B, F]), or exposed to the fluorescein-assisted protocol (“Fl-4@10”; 2 mg of fluorescein followed 10 minutes later by 54 K lux; [C, G]). Eyes for histology were collected 21 days after treatment. Eyes for TUNEL staining were collected 3 days after treatment. (D) Outer nuclear thickness was measured on histology sections at 100-μm intervals in eyes without treatment (n = 5), 21 days after “Light-only” FCD-LIRD (n = 3), and 21 days after Fl-4@10 light (n = 5). Scale bars: (A) 100 μm, (E) 75 μm. Date of download: 10/29/2017 The Association for Research in Vision and Ophthalmology Copyright © 2017. All rights reserved.