Frederiek M. Lever, MD, Irene M. Lips, MD, PhD, Sjoerd P. M

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Quantification of Esophageal Tumor Motion on Cine-Magnetic Resonance Imaging Frederiek M. Lever, MD, Irene M. Lips, MD, PhD, Sjoerd P.M. Crijns, PhD, Onne Reerink, MD, PhD, Astrid L.H.M.W. van Lier, PhD, Marinus A. Moerland, PhD, Marco van Vulpen, MD, PhD, Gert J. Meijer, PhD International Journal of Radiation Oncology • Biology • Physics Volume 88, Issue 2, Pages 419-424 (February 2014) DOI: 10.1016/j.ijrobp.2013.10.036 Copyright © 2014 Elsevier Inc. Terms and Conditions

Fig. 1 (A) Coronal and (B) sagittal cine-magnetic resonance image of a lower esophageal tumor, with the reference point (white) for the tracking filter shown on the caudal tumor border. International Journal of Radiation Oncology • Biology • Physics 2014 88, 419-424DOI: (10.1016/j.ijrobp.2013.10.036) Copyright © 2014 Elsevier Inc. Terms and Conditions

Fig. 2 Representative craniocaudal motion pattern in 1 patient of a point tracked on the caudal tumor border. The variety in the end-inhale phase (peaks) and the stability of the end-exhale phase (troughs) are evident. International Journal of Radiation Oncology • Biology • Physics 2014 88, 419-424DOI: (10.1016/j.ijrobp.2013.10.036) Copyright © 2014 Elsevier Inc. Terms and Conditions

Fig. 3 Range covering 95% of tumor motion (c95) in the cranio caudal direction and the standard deviation (SD) of the exhale and inhale peaks, illustrating the stability of the end-exhale position independently of the degree of motion compared with a greater variety in the end-inhale position. International Journal of Radiation Oncology • Biology • Physics 2014 88, 419-424DOI: (10.1016/j.ijrobp.2013.10.036) Copyright © 2014 Elsevier Inc. Terms and Conditions

Fig. 4 Scatter plots showing the mean c95 for upper, middle, and lower tumors in the (A) craniocaudal, (B) left–right, and (C) anteroposterior directions. Data were analyzed using 1-way analysis of variance with Bonferroni's multiple comparison tests. c95 represents the bandwidth covering 95% of tumor motion. Asterisks over the respective data pair indicate significant P values (*P=.023, **P=.001, ***P=.003). International Journal of Radiation Oncology • Biology • Physics 2014 88, 419-424DOI: (10.1016/j.ijrobp.2013.10.036) Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure E1 International Journal of Radiation Oncology • Biology • Physics 2014 88, 419-424DOI: (10.1016/j.ijrobp.2013.10.036) Copyright © 2014 Elsevier Inc. Terms and Conditions