Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology Improved Diagnosis of the Number of Stenosed Coronary Artery Vessels by Segmentation with Scatter and Photo-peak Window Data for Attenuation Correction in Myocardial Perfusion SPECT Yohei Yamauchi, MD,1 Yumiko Kanzaki, MD,1 Masuo Hayashi, RT,2 Mami Arai, RT,2 Hideaki Morita, MD,1 Tsuyoshi Komori, MD,2 Nobukazu Ishizaka, MD,1 Masaaki Hoshiga, MD,1 Department of Cardiology and Radiology OSAKA MEDICALL COLLEGE Copyright American Society of Nuclear Cardiology

Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology BACKGROUND 1- Attenuation correction using segmentation of scatter and photo-peak window data (SSPAC) enables an evaluation of the attenuation map in a patient-specific manner without additional radiation exposure. 2- We have previously shown that this method provides improved diagnostic accuracy for coronary artery disease. 3- Several attenuation correction methods have been reported that show improved accuracy for identifying the number of narrowing coronary vessels among patients with multi-vessel disease. 4- In the present study, we investigated whether it is clinically feasible to estimate the number of diseased coronary artery vessels using the SSPAC method. Copyright American Society of Nuclear Cardiology

METHODS Study type: Retrospective/observational Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology METHODS Study type: Retrospective/observational Study subjects: We examined 183 consecutive patients who had no prior myocardial infarction, and who underwent 99mTc-tetrofosmin stress/rest gated myocardial SPECT and coronary angiography within 3 months. Study endpoints: We compared the accuracy of the quantitative interpretation using summed differential score in the detection of coronary artery disease using with and without SSPAC imaging. Study variables ・Reconstruction algorisms (SSPAC image vs Non-correction image). ・Cardiac functional evaluation software programs (QGS). Copyright American Society of Nuclear Cardiology

Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology METHODS Copyright American Society of Nuclear Cardiology

Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology RESULTS Table 3. Vessel-based diagnostic ability of SSPAC and non-correction images in the detection of coronary artery disease in total 537 vessels from 179 patients. Table 4. Diagnostic ability of non-correction and SSPAC images in the detection of coronary artery disease based on the territory of vessels in 38 patients with multi-vessel disease. Copyright American Society of Nuclear Cardiology

Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology CONCLUSIONS The SSPAC method of stress-induced SPECT may provide improved sensitivity in the presence of stenosed coronary artery vessels, even in patients with multi-vessel CAD. Copyright American Society of Nuclear Cardiology