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From: Current Concepts in the Molecular Pathogenesis of Thyroid-Associated Ophthalmopathy Invest. Ophthalmol. Vis. Sci.. 2014;55(3):1735-1748. doi:10.1167/iovs.14-14002 Figure Legend: (A) Similar spindle-shaped phenotypes among orbital fibroblasts, dermal fibroblasts, and fibrocytes (hematoxylin and eosin, ×20). (B) Fibrocytes from individuals with GD display cell surface receptor CD34. 1, Immunofloresence staining of CD34 in TAO-derived tissue (inset as negative control). 2, Absence of CD34 expression in healthy orbital tissue (inset as positive control). (C) Orbital fibroblasts from individuals with and without TAO display similar receptors on fibrocytes, as shown by flow cytometric analysis with anti-CD34 and anti-Col I antibodies. Reprinted with permission from Douglas RS, Afifiyan NF, Hwang CJ, et al. Increased generation of fibrocytes in thyroid-associated ophthalmopathy. J Clin Endocrinol Metab. 2010;95:430–438. Copyright 2010 The Endocrine Society. Date of download: 10/29/2017 The Association for Research in Vision and Ophthalmology Copyright © 2017. All rights reserved.