Control of Metabolic Pathways

Slides:



Advertisements
Similar presentations
GENE REGULATION Virtually every cell in your body contains a complete set of genes But they are not all turned on in every tissue Each cell in your body.
Advertisements

Genetic Control of Growth
THE lac OPERON © 2007 Paul Billiet ODWS.
The lac Operon of E. Coli AMATH 882 Lecture 8, Feb. 7, 2011.
Genetic Regulatory Mechanisms
THE lac OPERON. The control of gene expression Each cell in the human contains all the genetic material for the growth and development of a human Some.
Section 12 – 5 Gene Regulation
Operon and Plasmid Review. The control of gene expression Each cell in the human contains all the genetic material for the growth and development of a.
THE LAC OPERON TANVI BAGTHARIA I P O Z Y.
AP Biology Chapter 18: Gene Regulation. Regulation of Gene Expression Important for cellular control and differentiation. Understanding “expression” is.
Differentiation Cell & Molecular Biology. Genetic Control All cells in the body have the same genetic information Not all cells are identical. Cellular.
Four of the many different types of human cells: They all share the same genome. What makes them different?
Prokaryotic and Eukaryotic Gene Regulation.  Regulatory gene  Transcriptional control  Posttranscriptional  Translational control  Posttranslational.
Gene Expression Cells use information in genes to build hundreds of different proteins, each with a specific function. But, not all proteins are required.
Gene Expression and Regulation
Gene Regulation Gene Regulation in Prokaryotes – the Jacob-Monad Model Gene Regulation in Prokaryotes – the Jacob-Monad Model certain genes are transcribed.
Name the four different types of gene mutation. Identify the ones that can potentially be more harmful and give a reason for why. Point mutations: these.
The Lac Operon An operon is a length of DNA, made up of structural genes and control sites. The structural genes code for proteins, such as enzymes.
CONTROL OF GENE EXPRESSION The development of an organism must involve the switching on and off of genes in an orderly manner. This is not fully understood.
How Does A Cell Know? Which Gene To Express Which Gene To Express& Which Gene Should Stay Silent? Which Gene Should Stay Silent?
Gene Expression and Regulation
Are genes always being transcribed and translated?
Metabolism and Enzymes
Cell metabolism. Metabolism encompasses the integrated and controlled pathways of enzyme catalysed reactions within a cell Metabolism The word “metabolism”
Higher Human Biology Unit 1 Human Cells KEY AREA 6: Metabolic Pathways.
Control of Metabolic Pathways Higher Human Biology Unit 1 – Section 6 Metabolic Pathways.
The control of gene expression enable individual bacteria to adjust their meta- bolism to environmental change.
OPERONS – GENES THAT CODE FOR ENZYMES ON THE SAME PATHWAY ARE REGULATED AS A GROUP.
6D – Recognize that a gene expression is a regulated process.
Higher Human Biology Subtopic 6 (b)
Operons In E. coli, all 5 genes that code for the production of the enzymes that make tryptophan (when necessary) are all located together Benefit: A single.
THE lac OPERON © 2016 Paul Billiet ODWS.
Gene Expression and Regulation
Control of Gene Expression
6D – Recognize that a gene expression is a regulated process.
Human Cells Metabolic pathways
THE lac OPERON © 2016 Paul Billiet ODWS.
The lac Operon of E. Coli AMATH 882 Lecture 11, Feb. 12, 2013
Higher Biology Metabolism & Enzymes Mr G R Davidson.
Section 6 – Metabolism & Enzymes
Control of Gene Expression
Metabolic Pathways (b)
Control of Prokaryotic (Bacterial) Genes
THE lac OPERON © 2007 Paul Billiet ODWS.
Regulation of Gene Expression
Add to your concept map Write all the key words from last lesson – leave some space so you can add more in coming lessons (2 word trigger meaning with.
Control of Prokaryotic (Bacterial) Genes
Turning Genes On and Off
Heredity, Gene Regulation, and Development
Higher Human Biology Unit 1 – Human Cells
Control Mechanisms.
Section 6 – Metabolism & Enzymes
Control of Prokaryotic (Bacterial) Genes
Gene Expression AP Biology.
Control of Prokaryotic (Bacterial) Genes
Control of Prokaryotic (Bacterial) Genes Different from Eukaryotes!
Gene Regulation certain genes are transcribed all the time – constitutive genes synthesis of some proteins is regulated and are produced only when needed.
Regulation of Gene Expression
The control of gene expression enable individual
Control of Prokaryotic (Bacterial) Genes
Control of Prokaryotic (Bacterial) Genes
Transcriptional Regulation in Prokaryotes.
Principles of Molecular Biology
Metabolism & Survival Key Area 1c Lac operon.
THE lac OPERON © 2016 Paul Billiet ODWS.
Chapter 18 Bacterial Regulation of Gene Expression
GENE REGULATION Virtually every cell in your body contains a complete set of genes But they are not all turned on in every tissue Each cell in your body.
Prokaryotic (Bacterial) Gene Regulation
Regulation of Gene Transcription
THE lac OPERON © 2007 Paul Billiet ODWS.
Presentation transcript:

Control of Metabolic Pathways Higher Human Biology Unit 1 – Human Cells

Metabolic Pathways Consist of several stages One metabolite is coverted to another and so on Each step is controlled by an enzyme Each enzyme (protein) is coded for by a gene (basic)

If the enzymes are present, the pathway proceeds If one enzyme is absent, the pathway comes to a halt Gene(s) Gene(s) Gene(s)

This enzyme action can be regulated at the level of gene expression (as follows) or enzyme action (which we’ll come to later)

Control by switching genes on and off To prevent wasted resources, some genes that code for enzymes are switched on and off as required.

E.g. Lactose Metabolism in E.coli Lactose is a sugar found in milk Glucose Galactose

Background Glucose is used in respiration by E.coli for energy release E.coli can only make use of glucose in lactose if it is released from galactose This is done by ß-galactosidase (enzyme) E.coli’s chromosome has a gene that codes for ß-galactosidase E.coli only produces ß-galactosidase in the presence of lactose (gene is switched on) It fails to produce ß-galactosidase if lactose is absent (or if only glucose is present) (gene is switched off)

LAC operon video This is the same video that is on the website We call the lactose an inducer as it prevents the repressor binding to the operator gene. It leads to the induction of ß-galactosidase.

Jacob Monod Hypothesis The hypothesis of gene action was first put forward by two scientists – Jacob and Monod. It has since been supported by experimental evidence from bacterial investigations.