Automatic Optimization of Cardiac Resynchronization Therapy Using SonR—Rationale and Design of the Clinical Trial of the SonRtip Lead and Automatic AV-VV.

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Presentation transcript:

Automatic Optimization of Cardiac Resynchronization Therapy Using SonR—Rationale and Design of the Clinical Trial of the SonRtip Lead and Automatic AV-VV Optimization Algorithm in the Paradym RF SonR CRT-D (RESPOND CRT) Trial Josep Brugada, MD, PhD, Johannes Brachmann, MD, Peter Paul Delnoy, MD, PhD, Luigi Padeletti, MD, PhD, Dwight Reynolds, MD, Philippe Ritter, MD, Alberto Borri-Brunetto, MSc, Jagmeet P. Singh, MD, PhD American Heart Journal Volume 167, Issue 4, Pages 429-436 (April 2014) DOI: 10.1016/j.ahj.2013.12.007 Copyright © 2014 The Authors Terms and Conditions

Figure 1 RESPOND CRT study flow chart. American Heart Journal 2014 167, 429-436DOI: (10.1016/j.ahj.2013.12.007) Copyright © 2014 The Authors Terms and Conditions

Figure 2 SonR amplitude (g) plotted against AV delays (ms) for the optimal VV configuration. The optimal atrioventricular delays value is that corresponding to the point of inflexion of this sigmoid curve. American Heart Journal 2014 167, 429-436DOI: (10.1016/j.ahj.2013.12.007) Copyright © 2014 The Authors Terms and Conditions

Figure 3 Decision algorithm for evaluation of the effectiveness end point. American Heart Journal 2014 167, 429-436DOI: (10.1016/j.ahj.2013.12.007) Copyright © 2014 The Authors Terms and Conditions