Volume 128, Issue 6, Pages 3838-3845 (December 2005) Skeletal Muscle Adaptations to Interval Training in Patients With Advanced COPD  Vogiatzis Ioannis , PhD, Terzis Gerasimos , PhD, Nanas Serafeim , MD, Stratakos Grigoris , MD, Simoes Davina C.M. , PhD, Georgiadou Olga , MSc, Zakynthinos Spyros , MD, Roussos Charis , MD, PhD  CHEST  Volume 128, Issue 6, Pages 3838-3845 (December 2005) DOI: 10.1378/chest.128.6.3838 Copyright © 2005 The American College of Chest Physicians Terms and Conditions

Figure 1 Average values for training intensity sustained during the program sessions (top left, A), cardiac frequency (fc) [bottom left, B], dyspnea (top right, C), and leg discomfort (bottom right, D) for the IE (open circles) and CLE (closed circles) training groups. All parameters are expressed as fractions of the peak values achieved at Wpeak during the baseline incremental test. Data are shown as mean ± SEM. CHEST 2005 128, 3838-3845DOI: (10.1378/chest.128.6.3838) Copyright © 2005 The American College of Chest Physicians Terms and Conditions

Figure 2 Fiber-type distribution (percentage) of the vastus lateralis muscle before (open squares) and after (gray squares) training for the IE group (top, A) and the CLE group (bottom, B). *p < 0.05, comparisons between before (open squares) and after training (gray squares). Data are presented as mean ± SEM. CHEST 2005 128, 3838-3845DOI: (10.1378/chest.128.6.3838) Copyright © 2005 The American College of Chest Physicians Terms and Conditions

Figure 3 Changes in the CSA of the different fiber types of the vastus lateralis muscle following IE training (top, A) and CLE training (bottom, B). *p < 0.05, comparisons between before (open squares) and after training (gray squares). Data are presented as mean ± SEM. CHEST 2005 128, 3838-3845DOI: (10.1378/chest.128.6.3838) Copyright © 2005 The American College of Chest Physicians Terms and Conditions

Figure 4 Changes in the capillary-to-fiber ratio (top, A), PFK (center, B), and CS activity (bottom, C) of IE training and CLE training. *p < 0.05, comparisons between before (open squares) and after training (gray squares). Data are presented as mean ± SEM. CHEST 2005 128, 3838-3845DOI: (10.1378/chest.128.6.3838) Copyright © 2005 The American College of Chest Physicians Terms and Conditions