C. R. Flannery, N. Moran, D. Blasioli, K. Donahue, J. Kane, T

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Presentation transcript:

Efficacy of a novel, locally delivered TrkA inhibitor in preclinical models of OA and joint pain C.R. Flannery, N. Moran, D. Blasioli, K. Donahue, J. Kane, T. Gladysheva, R. Dagher, R. Fang, A. Vardanyan, D. Bangari, C. Ho, A. Bourque, M. Santos, M. Philbrook, G.L. Matthews Osteoarthritis and Cartilage Volume 23, Pages A45-A46 (April 2015) DOI: 10.1016/j.joca.2015.02.100 Copyright © 2015 Terms and Conditions

Figure 1. Efficacy of GZ389988 in rat MIA model of joint pain Figure 1. Efficacy of GZ389988 in rat MIA model of joint pain. Disease was initiated by a single IA injection of MIA into the knee joint (ipsilateral). One week later, a single dose of GZ389988 was administered by IA injection into the ipsilateral or contralateral knee. Differences in hind limb weight-bearing distribution were measured immediately prior to injection of MIA (baseline; BL) and GZ389988 (Time 0), and weekly thereafter for 4 weeks. Data are presented as mean + SEM. Osteoarthritis and Cartilage 2015 23, A45-A46DOI: (10.1016/j.joca.2015.02.100) Copyright © 2015 Terms and Conditions

Figure 2. Efficacy of GZ389988 in rat PGPS model of joint pain Figure 2. Efficacy of GZ389988 in rat PGPS model of joint pain. Disease was inititated by a single IA injection of PGPS into the knee joint (ipsilateral) three weeks prior to the first reactivation. A single dose of GZ389988 was administered by IA injection into the knee one week prior to the first reactivation. Disease reactivation (painful flare) was induccd on study days 0 and 14 by IV administration of PGPS. Gait analysis was performed based on pawprint areas, and scored as follows: 1= mild limping/pain; 2=moderate limping/pain; 3=marked limping/pain; 4=severe hopping/pain. Data are presented as mean + SEM. Osteoarthritis and Cartilage 2015 23, A45-A46DOI: (10.1016/j.joca.2015.02.100) Copyright © 2015 Terms and Conditions