From: Computational methods for identifying miRNA sponge interactions

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From: Computational methods for identifying miRNA sponge interactions Figure 1 miRNA sponge mechanism. The four types of miRNA sponges are shown each containing binding sites (short rectangles) for a miRNA of interest (semi-circle). (A) The miRNA sponges have lost the competition, the target mRNA will be post-transcriptionally repressed by the miRNA and degraded. (B) The miRNA sponges have won the competition, the miRNA is freed from regulating the target mRNA, and the target mRNA will be released of repression and translated into protein. A colour version of this figure is available at BIB online: https://academic.oup.com/bib. From: Computational methods for identifying miRNA sponge interactions Brief Bioinform. 2016;18(4):577-590. doi:10.1093/bib/bbw042 Brief Bioinform | © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

From: Computational methods for identifying miRNA sponge interactions Figure 2 The number of ceRNA or miRNA sponge related publications in the past 8 years. The number of related publications is from PubMed library with the keyword ‘ceRNA’ or ‘miRNA sponge’. A colour version of this figure is available at BIB online: https://academic.oup.com/bib. From: Computational methods for identifying miRNA sponge interactions Brief Bioinform. 2016;18(4):577-590. doi:10.1093/bib/bbw042 Brief Bioinform | © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

From: Computational methods for identifying miRNA sponge interactions Figure 3 Overlaps and differences between miRNA sponge interactions identified by PC, CMI, PPC, and SPPC. (A) lncRNA-lncRNA interactions. (B) lncRNA-mRNA interactions. (C) mRNA-mRNA interactions. A colour version of this figure is available at BIB online: https://academic.oup.com/bib. From: Computational methods for identifying miRNA sponge interactions Brief Bioinform. 2016;18(4):577-590. doi:10.1093/bib/bbw042 Brief Bioinform | © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com