Strong correlation between tax and HBZ mRNA expression in HAM/TSP patients: Distinct markers for the neurologic disease Rafaela Gomes Andrade, Poliane.

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Strong correlation between tax and HBZ mRNA expression in HAM/TSP patients: Distinct markers for the neurologic disease Rafaela Gomes Andrade, Poliane de Cássia Gonçalves, Maisa Aparecida Ribeiro, Luiz Cláudio Ferreira Romanelli, João Gabriel Ribas, Elídio Barbosa Torres, Anna Bárbara de Freitas Carneiro-Proietti, Edel Figueiredo Barbosa-Stancioli, Marina Lobato Martins Journal of Clinical Virology Volume 56, Issue 2, Pages 135-140 (February 2013) DOI: 10.1016/j.jcv.2012.10.003 Copyright © 2012 Elsevier B.V. Terms and Conditions

Fig. 1 HTLV-1 proviral load in PBMC sampled from 37 asymptomatic carriers and 26 HAM/TSP patients. The individuals were classified into AC and HAM subgroups with low (L: <1%) or high (H: >1%) proviral load. The HTLV-1 proviral load was significantly different among each subgroup (ACL vs. ACH: p<0.001, ACL vs. HAML: p=0.011, ACL vs. HAMH: p<0.001, ACH vs. HAML: p<0.001, HAML vs. HAMH: p<0.001), except for the ACH subgroup vs. the HAMH subgroup (p=0.162). The solid line indicates 1% proviral load (100 proviral copies/104 cells). The medians are shown as dotted lines. Statistical differences were calculated with the Mann–Whitney U test. Journal of Clinical Virology 2013 56, 135-140DOI: (10.1016/j.jcv.2012.10.003) Copyright © 2012 Elsevier B.V. Terms and Conditions

Fig. 2 HTLV-1 tax and HBZ mRNA expression normalized by HTLV-1-infected cells. (A, B) Tax and HBZ mRNA load per provirus DNA copies. There was a significant difference in tax mRNA normalized by the proviral DNA between AC and HAM patients, but not for sHBZ mRNA normalized by the proviral DNA. (C, D) Tax and HBZ mRNA load per proviral DNA copies in the subgroups of AC and HAM patients with low (ACL and HAML) or high (ACH and HAMH) proviral load. For tax mRNA, the expression was significantly different between the ACL vs. ACH and ACL vs. HAMH whereas for HBZ mRNA, the expression was not significantly different among the four subgroups. The medians are shown as dotted lines. Statistical differences were calculated with the Mann–Whitney U test. Journal of Clinical Virology 2013 56, 135-140DOI: (10.1016/j.jcv.2012.10.003) Copyright © 2012 Elsevier B.V. Terms and Conditions