By: Julie Carrasco, Brianna Macias, Alexx Rusake

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Presentation transcript:

By: Julie Carrasco, Brianna Macias, Alexx Rusake Multiple Sclerosis By: Julie Carrasco, Brianna Macias, Alexx Rusake

Origin Discovered by Jean-Martin Charcot in 1868 Recognized in 1873 by Dr. Walter Moxon in England and in 1878 by Dr. Edward Seguin in the U.S.

Quick Intro Multiple Sclerosis is a disease that affects the brain and spinal cord Nerves of the brain and spinal cord are damaged by own immune system (autoimmune disease) Loss of muscle control, vision, balance and sensation Disease becoming more common About 250,000-350,000 people with MS in the U.S More common in Northern Europe and in white people 4 types: relapsing- remitting, primary-progressive, secondary-progressive, progressive-relapsing

Cause No one is sure of the cause Some say it is a combination of genetics and something you are exposed to environmentally early in life Viruses like Epstein-Barr, Varicella Zoster, and the Hepatitis vaccine might be a possible cause (still not proven) Hormones, including sex hormones, can affect and be affected by the immune system (estrogen & progesterone and testosterone) Higher levels of testosterone in men might be why women with MS are more common than men

Symptoms Muscle weakness Fatigue Decreased coordination Blurred or hazy vision Double vision Depression/emotional changes Pain or numbness Slurred speech and stuttering

Treatment Slow the disease: Beta Interferons Glatiramer acetate Fingolimod Teriflunomide Mitoxantrone Treat attacks: Corticosteroids: Reduce inflammation that happens during relapse Plasma exchange (plasmapheresis): To help with severe symptoms of MS for people that aren’t responding to the steroids Treat symptoms: Physical therapy Dalfampridine (Ampyra): Improve walking speed -Side effect: Seizures Muscle relaxants: Improve muscle spasticity -Baclofen (Lioresal) -Tizanidine (Zanaflex)

Prognosis Hard to determine life expectancy Approximate life expectancy is 25-35 years after diagnosis Affects quality of life, not quantity Death is mainly caused by secondary complications: heart disease, cancer, stroke, and suicide No current cure for M.S

Research Mission : Stop disease progression, restore what has been lost, and to end MS forever National Multiple Sclerosis Society : searches identifying targets and repurposing opportunities for progressive MS, uses experimental models for preclinical evaluation of therapies, clinical outcome, and symptom management Cell therapy, myelin therapy, and immune system therapy all in clinical trials Just started researching how to repair nervous system