Continued Smoking Exacerbates but Cessation Ameliorates Progression of Early Type 2 Diabetic Nephropathy Kantima Phisitkul, MD, Khaled Hegazy, MD, Temduang.

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Presentation transcript:

Continued Smoking Exacerbates but Cessation Ameliorates Progression of Early Type 2 Diabetic Nephropathy Kantima Phisitkul, MD, Khaled Hegazy, MD, Temduang Chuahirun, MD, Cathy Hudson, CCRC The American Journal of the Medical Sciences Volume 335, Issue 4, Pages 284-291 (April 2008) DOI: 10.1097/MAJ.0b013e318156b799 Copyright © 2008 Southern Society for Clinical Investigation Terms and Conditions

Figure 1 Glomerular filtration rate estimated using the modification of diet in renal disease formula (eGFR) during 5-year follow-up of the first cohort of prospectively followed, nonsmoking subjects with type 2 diabetes mellitus (DM2) and either normoalbuminuria (Normo), microalbuminuria (Micro), or macroalbuminuria (Macro). *P < 0.05 versus Normo; +P < 0.05 versus Micro. The American Journal of the Medical Sciences 2008 335, 284-291DOI: (10.1097/MAJ.0b013e318156b799) Copyright © 2008 Southern Society for Clinical Investigation Terms and Conditions

Figure 2 Urine albumin excretion (UalbuminV) expressed as albumin (mg)-to-creatinine (g) ratio in a spot morning specimen of the first cohort of prospectively followed, nonsmoking Normo, Micro, or Macro DM2 subjects during the 5-year follow-up. *P < 0.05 versus respective baseline value. The American Journal of the Medical Sciences 2008 335, 284-291DOI: (10.1097/MAJ.0b013e318156b799) Copyright © 2008 Southern Society for Clinical Investigation Terms and Conditions

Figure 3 Urine cotinine excretion (UcotinineV) during 5-year follow-up in the second cohort of prospectively followed DM2 subjects with early nephropathy (microalbuminuria) who were nonsmokers, continued smokers, and quitting smokers. *P < 0.05 versus nonsmokers. The American Journal of the Medical Sciences 2008 335, 284-291DOI: (10.1097/MAJ.0b013e318156b799) Copyright © 2008 Southern Society for Clinical Investigation Terms and Conditions

Figure 4 Urine albumin excretion (UalbuminV) expressed as albumin (mg)-to-creatinine (g) ratio in a spot morning specimen during the 5-year follow-up in the second cohort of prospectively followed DM2 subjects with early nephropathy (microalbuminuria) who were nonsmokers, continued smokers, and quitting smokers. *P < 0.05 versus nonsmokers. The American Journal of the Medical Sciences 2008 335, 284-291DOI: (10.1097/MAJ.0b013e318156b799) Copyright © 2008 Southern Society for Clinical Investigation Terms and Conditions

Figure 5 Urine excretion of isoprostane 8-prostaglandin F2α (U8-isoV), expressed as (μg)-to-creatinine (g) ratio in a spot morning specimen during 5-year follow-up in the second cohort of prospectively followed DM2 subjects with early nephropathy (microalbuminuria) who were nonsmokers, continued smokers, and quitting smokers. *P < 0.05 versus nonsmokers. The American Journal of the Medical Sciences 2008 335, 284-291DOI: (10.1097/MAJ.0b013e318156b799) Copyright © 2008 Southern Society for Clinical Investigation Terms and Conditions