Hierarchical clustering of DEGs in Shp−/− mice, chronic hepatitis C cirrhosis, and NASH. A: unsupervised hierarchical clustering of genes common to the.

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Hierarchical clustering of DEGs in Shp−/− mice, chronic hepatitis C cirrhosis, and NASH. A: unsupervised hierarchical clustering of genes common to the NASH microarray and chronic hepatitis C cirrhosis and Shp−/− RNA-seq gene expression arrays. Hierarchical clustering of DEGs in Shp−/− mice, chronic hepatitis C cirrhosis, and NASH. A: unsupervised hierarchical clustering of genes common to the NASH microarray and chronic hepatitis C cirrhosis and Shp−/− RNA-seq gene expression arrays. B: heat map showing supervised hierarchical clustering of genes with fold changes in expression greater than or equal to ±5-fold in Shp−/− compared with WT mice depicting potential SHP-activated genes in group 1 and SHP-repressed genes in group 2. C: heat map showing supervised hierarchical clustering of selected genes with fold changes greater than or equal to ±1.5 in both cirrhotic compared with normal livers and in Shp−/− compared with WT livers, demonstrating correlation between the disease state and Shp−/− gene expression, those repressed in chronic hepatitis C cirrhosis in group 3 and activated in group 4. D: similar to chronic hepatitis C cirrhosis, this heat map shows selected genes with fold changes greater than or equal to ±1.5-fold in NASH compared with normal livers common in Shp−/− compared with WT livers and has a similar pattern. Rana L. Smalling et al. Am J Physiol Gastrointest Liver Physiol 2013;305:G364-G374 ©2013 by American Physiological Society