ORSOMEX

Collagen Most abundant insoluble fibrous protein in the connective tissue of mammals Makes up to 25%-35% of the whole body protein content It comes from the Greek work “kolla” which means glue. It is also called glue-producer It is found in mucous membranes, nerves, blood vessels and organs

Collagen content in the organs

Hydrolyzed Collagen Produced from collagen found in the bones, skin, and connective tissue of animals. Hydrolysis involves breaking down the molecular bonds between individual collagen strands and peptides using combinations of physical, chemical or biological means

Hydrolysis Hydrolysis results in the reduction of collagen protein fibrils of about 300,000 Da into smaller peptides The amino acid content of hydrolyzed collagen is the same as collagen.

Amino acid composition Hydrolyzed collagen contains 19 amino acids, predominantly glycine, proline and hydroxyproline, which together represent around 50% of the total amino acid content Hydrolyzed collagen contains 8 out of 9 essential amino-acids, including glycine and arginine—two amino-acid precursors necessary for the biosynthesis of creatine

Digestion More than 90% absorbed within 6 hours, with measurable accumulation in cartilage and skin A 2005 study in humans found hydrolyzed collagen absorbed as small peptides in the blood

Effects on skin Ingestion of hydrolyzed collagen may affect the skin by increasing the density of collagen fibrils and fibroblasts, thereby stimulating collagen production. It has been suggested, based on mouse and in vitro studies, that hydrolyzed collagen peptides have chemotactic properties on fibroblasts or an influence on growth of fibroblasts.

Effects on joints Some clinical studies report that the oral ingestion of hydrolyzed collagen decreases joint pain, those with the most severe symptoms showing the most benefit. Beneficial action is likely due to hydrolyzed collagen accumulation in the cartilage and stimulated production of collagen by the chondrocytes, the cells of cartilage

Effects on muscle and bone Several studies have shown that a daily intake of hydrolyzed collagen increases bone mass density in rats. It seems that hydrolyzed collagen peptides stimulated differentiation and osteoblasts activity- the cells that build bone- over that of osteoclasts (cells that destroy bone).

Advantages Well tolerated by the digestive system Hydrolyzed so easily absorbed by the body Orsomex is Natural bioactive product Orsomex is a high purity hydrolyzed collagen