Wan-Jie Gu, MSc, Chun-Yin Wei, MSc, Rui-Xing Yin, MD, PhD CHEST

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Lack of Efficacy of Probiotics in Preventing Ventilator-Associated Pneumonia Wan-Jie Gu, MSc, Chun-Yin Wei, MSc, Rui-Xing Yin, MD, PhD CHEST Volume 142, Issue 4, Pages 859-868 (October 2012) DOI: 10.1378/chest.12-0679 Copyright © 2012 The American College of Chest Physicians Terms and Conditions

Figure 1 Selection process for RCTs included in the meta-analysis. RCT = randomized controlled trial; VAP = ventilator-associated pneumonia. CHEST 2012 142, 859-868DOI: (10.1378/chest.12-0679) Copyright © 2012 The American College of Chest Physicians Terms and Conditions

Figure 2 Meta-analysis of RCTs evaluating effects of probiotics on the incidence of VAP. There was no significant effect in preventing VAP as determined by the random-effects model. See Figure 1 legend for expansion of abbreviations. CHEST 2012 142, 859-868DOI: (10.1378/chest.12-0679) Copyright © 2012 The American College of Chest Physicians Terms and Conditions

Figure 3 Meta-analysis of RCTs evaluating effects of probiotics on ICU mortality. There was no significant effect on ICU mortality as determined by the random-effects model. See Figure 1 legend for expansion of abbreviation. CHEST 2012 142, 859-868DOI: (10.1378/chest.12-0679) Copyright © 2012 The American College of Chest Physicians Terms and Conditions

Figure 4 Meta-analysis of RCTs evaluating effects of probiotics on hospital mortality. There was no significant effect on hospital mortality as determined by the random-effects model. See Figure 1 legend for expansion of abbreviation. CHEST 2012 142, 859-868DOI: (10.1378/chest.12-0679) Copyright © 2012 The American College of Chest Physicians Terms and Conditions