Effect of oleuropein against chemotherapy drug-induced histological changes, oxidative stress, and DNA damages in rat kidney injury Fatime Geyikoglu,

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Effect of oleuropein against chemotherapy drug-induced histological changes, oxidative stress, and DNA damages in rat kidney injury Fatime Geyikoglu, Murat Emir, Suat Colak, Kubra Koc, Hasan Turkez, Murat Bakir, Mirkhalil Hosseinigouzdagani, Salim Cerig, Osman Nuri Keles, Nihal Simsek Ozek Journal of Food and Drug Analysis Volume 25, Issue 2, Pages 447-459 (April 2017) DOI: 10.1016/j.jfda.2016.07.002 Copyright © 2016 Terms and Conditions

Figure 1 The effects of OLE on kidney MDA level after treated with cisplatin. (Data are presented as mean ± SD (n = 7). Different letters indicate significant differences between studied groups at p < 0.05. CIS: cisplatin; MDA: malondialdehyde; OLE: oleuropein; SD: standard deviation. Journal of Food and Drug Analysis 2017 25, 447-459DOI: (10.1016/j.jfda.2016.07.002) Copyright © 2016 Terms and Conditions

Figure 2 The effects of OLE on kidney TOS level after treated with cisplatin. (Data are presented as mean ± SD (n = 7). Different letters indicate significant differences between studied groups at p < 0.05. CIS: cisplatin; OLE: oleuropein; TOS: total oxidative status; SD: standard deviation. Journal of Food and Drug Analysis 2017 25, 447-459DOI: (10.1016/j.jfda.2016.07.002) Copyright © 2016 Terms and Conditions

Figure 3 The effects of OLE on serum BUN level after treated with cisplatin. (Data are presented as mean ± SD (n = 7). Different letters indicate significant differences between studied groups at p < 0.05. BUN: blood urea nitrogen; CIS: cisplatin; OLE: oleuropein; SD: standard deviation. Journal of Food and Drug Analysis 2017 25, 447-459DOI: (10.1016/j.jfda.2016.07.002) Copyright © 2016 Terms and Conditions

Figure 4 The effects of OLE on serum CRE level after treated with cisplatin. (Data are presented as mean ± SD (n = 7). Different letters indicate significant differences between studied groups at p < 0.05. CIS: cisplatin; CRE: creatinine; OLE: oleuropein, SD: standard deviation. Journal of Food and Drug Analysis 2017 25, 447-459DOI: (10.1016/j.jfda.2016.07.002) Copyright © 2016 Terms and Conditions

Figure 5 The effects of OLE on serum Uric acid (UA) level after treated with cisplatin. (Data are presented as mean ± SD (n = 7). Different letters indicate significant differences between studied groups at p < 0.05. CIS: cisplatin; OLE: oleuropein; SD: standard deviation; UA: uric acid. Journal of Food and Drug Analysis 2017 25, 447-459DOI: (10.1016/j.jfda.2016.07.002) Copyright © 2016 Terms and Conditions

Figure 6 The effects of OLE on kidney TAS level after treated with cisplatin. Data are presented as mean ± SD (n = 7). Different letters indicate significant differences between studied groups at p < 0.05. CIS: cisplatin; OLE: oleuropein; SD: standard deviation; TAS: total antioxidant status. Journal of Food and Drug Analysis 2017 25, 447-459DOI: (10.1016/j.jfda.2016.07.002) Copyright © 2016 Terms and Conditions

Figure 7 The control groups with normal kidney histology; (A) Kortex: G = glomerulus, P = proximal tubule, D = distal tubule, * = Bowman space; (B) medulla: D = distal tubule, H&E, ×200; (C) G = glomerulus, P = proximal tubule, D = distal tubule, * = Bowman space, arrows = Tubular basal membrane, PAS, ×200; (D) arrow = arteriole, Masson trichrome, ×200; (E) amyloid, ×200. H&E = hematoxylin-eosin; PAS = periodic acid Schiff. Journal of Food and Drug Analysis 2017 25, 447-459DOI: (10.1016/j.jfda.2016.07.002) Copyright © 2016 Terms and Conditions

Figure 8 The kidney histology in CIS group rats; (A) arrow = arteriosclerosis, * = congestion, I = lymphocyte infiltration; (B) F = fibrosis; (C) arrows = amyloid deposits; (D) T = tubular dilatation, arrows = tubular necrosis; (E) M = mesangial proliferation in glomeruli, * = congestion, I = lymphocyte infiltration, H&E, ×200; (F) pale and slightly stained cells, * = amyloid deposit, PAS, ×200; (G) arrow = interstitial fibrosis; (H) arrows = periglomerular fibrosis, G = glomerulus, Masson trichrome, ×200; (I) arrows = amyloid deposits, amyloid, ×200. CIS = cisplatin; H&E = hematoxylin-eosin; PAS = periodic acid Schiff. Journal of Food and Drug Analysis 2017 25, 447-459DOI: (10.1016/j.jfda.2016.07.002) Copyright © 2016 Terms and Conditions

Figure 9 The kidney histology in CIS + OLE group rats; (A) cisplatin + 50 mg/kg OLE group, arrows = Bowman space, * = congestion; (B) cisplatin + 100 mg/kg OLE group, T = tubules in medulla, H&E, ×200; (C) cisplatin + 100 mg/kg OLE group, arrows = Bowman space, PAS, ×200; (D) cisplatin + 100 mg/kg OLE group, arrows = periglomerular fibrosis, Masson trichrome, ×200; (E) cisplatin + 200 mg/kg OLE group, G = glomerulus, P = proximal tubule, D = distal tubule, H&E, ×200; (F) cisplatin + 200 mg/kg OLE group, G = glomerulus, P = proximal tubule, D = distal tubule, amyloid, ×200. CIS = cisplatin; H&E = hematoxylin-eosin; OLE = oleuropein; PAS = periodic acid Schiff. Journal of Food and Drug Analysis 2017 25, 447-459DOI: (10.1016/j.jfda.2016.07.002) Copyright © 2016 Terms and Conditions

Journal of Food and Drug Analysis 2017 25, 447-459DOI: (10. 1016/j Journal of Food and Drug Analysis 2017 25, 447-459DOI: (10.1016/j.jfda.2016.07.002) Copyright © 2016 Terms and Conditions