Triplet (FOLFOXIRI) versus doublet (FOLFOX or FOLFIRI) backbone chemotherapy as first-line treatment of metastatic colorectal cancer: A systematic review.

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Triplet (FOLFOXIRI) versus doublet (FOLFOX or FOLFIRI) backbone chemotherapy as first-line treatment of metastatic colorectal cancer: A systematic review and meta- analysis  Rui Pedro Marques, Gonçalo S. Duarte, Carmelo Sterrantino, Helena Luna Pais, António Quintela, Ana Paula Martins, João Costa  Critical Reviews in Oncology / Hematology  Volume 118, Pages 54-62 (October 2017) DOI: 10.1016/j.critrevonc.2017.08.006 Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 1 Flow chart. Flow diagram illustrating flow of studies identified from the search strategy and reasons for exclusion. Critical Reviews in Oncology / Hematology 2017 118, 54-62DOI: (10.1016/j.critrevonc.2017.08.006) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 2 Main outcomes. Aggregate results for the considered main outcomes: Overall Survival (OS), Progression Free Survival (PFS), Study withdrawals, Proportion of participants with grade ≥3 Adverse Events (AEs), and Total of grade ≥3 Adverse Events (AEs) reported. Horizontal lines represent 95% CIs. Critical Reviews in Oncology / Hematology 2017 118, 54-62DOI: (10.1016/j.critrevonc.2017.08.006) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 3 Secondary outcomes. Aggregate results for the considered additional outcomes: R0 resection rate, Metastases resection rate, Overall objective response rate, Complete response rate, Partial response rate, and Specific safety outcomes. Horizontal lines represent 95% CIs. Critical Reviews in Oncology / Hematology 2017 118, 54-62DOI: (10.1016/j.critrevonc.2017.08.006) Copyright © 2017 Elsevier B.V. Terms and Conditions

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