How can we create and analyze ‘new signals’ using ICM+?

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Presentation transcript:

How can we create and analyze ‘new signals’ using ICM+? Magdalena Kasprowicz How can we create and analyze ‘new signals’ using ICM+? ICM+ user’s club meeting 12 September 2010, Tubingen

What ‘new signals’ can be analysed using ICM+? Raw data: ABP and CBFV Cerebral arterial blood volume (CaBV) Cerebral arterial compliance (Ca) Cerebrovascular time constant of arterial bed () Raw data: ABP, CBFV and ICP Cerebrospinal + venous compliance (Ci) Intracranial compliance ceofficient (ICC)

Cerebral arterial inflow Cerebral venous outflow R-R interval of ECG mean CBV + - CBFa(t) CBFv(t) Cerebral arterial blood volume (CaBV) Cerebral arterial inflow mean CBFa Cerebral venous outflow CBV(t) t1 t2 Cerebral blood volume Avezaat CJ, van Eijndhoven JH. (1986) The role of the pulsatile pressure variations in intracranial pressure monitoring. Neurosurg Rev 9:113-120

Defining new virtual signals step by step

Cerebral arterial blood volume (CaBV) Integrate(fv-MovingAvgFilter(fv,300)) Integrate() MovingAvgFilter(,)

CaBV- Response to changes in EtCO2

Compartmental compliances of brain Cerebral arterial compliance (Ca) Cerebrospinal + venous compliance (Ci)

Cerebral arterial compliance (Ca) Mean(AMP_CaBV) / Mean(Amp_ABP) FundAmp(CBV,’BPM&LWR&=40&UPR=120’ FundAmp FundAmp(ABP,’BPM&LWR&=40&UPR=120’ FundAmp Since we have already defined CBV as a new virtual signal, now we cam move to promary analysis and calculate compliance

Ca - Response to changes in EtCO2

Compartmental compliances (Ca, Ci)

Intracranial compliance coefficient (ICC) Correl (Ci, Ca) Correl

Intracranial compliance coefficient (ICC)

Cerebrovascular time constant () Mean(Ca) * Mean (CVR) Mean(ABP) / Mean (FV)

- Response to changes in EtCO2 [mmHg] [cm/s] [kPa] [s]

Conclusions ICM+ data analysis is simple! ICM+ software provides: a graphical, user-friendly interface a comprehensive set of functions for data analysis basic operators (additon, substraction, etc) more complex time-domain function (mean, median, cross-correlation) frequency doamain function (power, fundamental frequency, coherence) a pipe-like data flow analysis virual signals (input)  primary analysis  secendary analysis  final anlysis number of ‘new signals’ which can be incorporated in the software ICM+ is unlimited

Cerebrovascular time constant in carotid artery occlusive disease Monday, September 13, 2010 10:20–11:40 ICP and the Cerebrovascular System Changes in cerebral compartmental compliances during mild hypocapnia in patients with traumatic brain injury E. Carrera, L. A. Steiner , G. Castellani, P. Smielewski, C. Zweifel, C. Haubrich, J. D. Pickard, D. Menon, M. Czosnyka Cerebrovascular time constant in carotid artery occlusive disease M. Kasprowicz , C. Haubrich, P. Smielewski, J. Diedler, E. Carrera, E. Sorrentino, Z. Czosnyka, J. D. Pickard, M. Czosnyka Wednesday, September 15, 2010 15:10–15:50 Severe TBI – Insights Continuous monitoring of Monro-Kellie doctrine in traumatic brain injury Dong-Joo Kim, M. Czosnyka, E. Carrera, C. Haubrich, Z. Czosnyka, M. Kasprowicz, P. Smielewski, M. Balestreri, A. Pena, O. Baledent, J. D. Pickard

Thank you