Copyright © 2004 American Medical Association. All rights reserved. From: Vitreous Levels of Vascular Endothelial Growth Factor and Stromal-DerivedFactor 1 in Patients With Diabetic Retinopathy and Cystoid Macular Edema Beforeand After Intraocular Injection of Triamcinolone Arch Ophthalmol. 2004;122(12):1801-1807. doi:10.1001/archopht.122.12.1801 Figure Legend: Triamcinolone appears as a whitishsuspension located in the inferior portion of the vitreous cavity. Date of download: 10/30/2017 Copyright © 2004 American Medical Association. All rights reserved.

Copyright © 2004 American Medical Association. All rights reserved. From: Vitreous Levels of Vascular Endothelial Growth Factor and Stromal-DerivedFactor 1 in Patients With Diabetic Retinopathy and Cystoid Macular Edema Beforeand After Intraocular Injection of Triamcinolone Arch Ophthalmol. 2004;122(12):1801-1807. doi:10.1001/archopht.122.12.1801 Figure Legend: Intravenous fluorescein angiogram(IVFA) of diffuse macular edema (DME). A, A preoperative steroid angiogramwith a transit time of 5 minutes shows hyperfluorescence, which is leakageof fluorescein dye into the retinal tissue from breakdown of the blood retinalbarrier. B, An IVFA at the same transit time 1 month after triamcinolone injectionshowing restoration of the blood retinal barrier manifested by lack of hyperfluorescenceand DME. Previous laser focal spots are clearly visible inferior temporalto fovea. Date of download: 10/30/2017 Copyright © 2004 American Medical Association. All rights reserved.

Copyright © 2004 American Medical Association. All rights reserved. From: Vitreous Levels of Vascular Endothelial Growth Factor and Stromal-DerivedFactor 1 in Patients With Diabetic Retinopathy and Cystoid Macular Edema Beforeand After Intraocular Injection of Triamcinolone Arch Ophthalmol. 2004;122(12):1801-1807. doi:10.1001/archopht.122.12.1801 Figure Legend: Optical coherence tomography (OCT)cross-section before triamcinolone corresponding to the intravenous fluoresceinangiogram (IVFA) in Figure 2. A, AnOCT shows diffuse macular edema (DME), retinal thickness of 728 μm, andvisual acuity of 20/100. B, An OCT 1 month after intravitreal triamcinolonecorresponding to the IVFA in Figure 2B showingsignificant decrease in DME and improvement of visual acuity to 20/50. Date of download: 10/30/2017 Copyright © 2004 American Medical Association. All rights reserved.

Copyright © 2004 American Medical Association. All rights reserved. From: Vitreous Levels of Vascular Endothelial Growth Factor and Stromal-DerivedFactor 1 in Patients With Diabetic Retinopathy and Cystoid Macular Edema Beforeand After Intraocular Injection of Triamcinolone Arch Ophthalmol. 2004;122(12):1801-1807. doi:10.1001/archopht.122.12.1801 Figure Legend: Intravenous fluorescein angiogram(IVFA) in a patient with active high-risk proliferative diabetic retinopathy(PDR). A, An IVFA shows venous segmentation, venous loops, and hyperfluorescencefrom aberrant neovascularization (NV) on the retina. The vascular endothelialgrowth factor (VEGF) level was 5146.7 ng/mL, and the stromal-derived factor1 (SDF-1) level was 1156.4 pg/mL. B, One month after triamcinolone injection,an IVFA shows marked reduction of venous segmentation and loops and markeddecrease in hyperfluorescence from NV. The VEGF level was 42 ng/mL, and theSDF-1 level was 0 pg/mL. Date of download: 10/30/2017 Copyright © 2004 American Medical Association. All rights reserved.

Copyright © 2004 American Medical Association. All rights reserved. From: Vitreous Levels of Vascular Endothelial Growth Factor and Stromal-DerivedFactor 1 in Patients With Diabetic Retinopathy and Cystoid Macular Edema Beforeand After Intraocular Injection of Triamcinolone Arch Ophthalmol. 2004;122(12):1801-1807. doi:10.1001/archopht.122.12.1801 Figure Legend: Quantification of intravitreal stromal-derivedfactor 1 (SDF-1) (A) and vascular endothelial growth factor (VEGF) (B) asmeasured by enzyme-linked immunosorbent assay immediately before and 1 monthafter intravitreal triamcinolone injection (P<.05).C and D depict a regression analysis (along with correlation) for scatterplotsof VEGF vs SDF for each of the 5 patient groups. The asterisks indicate asignificant difference between pretriamcinolone and posttriamcinolone values,and the error bars indicate SD. DME indicates diffuse macular edema; NPDR,nonproliferative diabetic retinopathy; NVI, neovascularization of the iris;and PDR, proliferative diabetic retinopathy. Date of download: 10/30/2017 Copyright © 2004 American Medical Association. All rights reserved.

Copyright © 2004 American Medical Association. All rights reserved. From: Vitreous Levels of Vascular Endothelial Growth Factor and Stromal-DerivedFactor 1 in Patients With Diabetic Retinopathy and Cystoid Macular Edema Beforeand After Intraocular Injection of Triamcinolone Arch Ophthalmol. 2004;122(12):1801-1807. doi:10.1001/archopht.122.12.1801 Figure Legend: Vitreous samples containing highstromal-derived factor 1 (SDF-1) levels (>6000 pg/mL), as shown by enzyme-linkedimmunosorbent assay, induce human retinal endothelial cell chemotaxis (dark-graybars) in a Boyden chamber assay. Preincubation of the cells with AMD3100,a potent antagonist of the SDF-1 receptor, reduces the chemotactic responseto levels approaching background (black bars). All conditions were run intriplicate using cells from 2 separate donors. The error bars indicate SD.CGM indicates complete growth medium (positive control); and SFM, serum-freemedium (negative control). Date of download: 10/30/2017 Copyright © 2004 American Medical Association. All rights reserved.