The see-saw of Keap1-Nrf2 pathway in cancer

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Presentation transcript:

The see-saw of Keap1-Nrf2 pathway in cancer Poorti Pandey, Alok Kumar Singh, Mritunjai Singh, Mallika Tewari, Hari Shankar Shukla, Indrajeet Singh Gambhir Critical Reviews in Oncology / Hematology Volume 116, Pages 89-98 (August 2017) DOI: 10.1016/j.critrevonc.2017.02.006 Copyright © 2017 Terms and Conditions

Fig 1 Flow diagram showing factors involved in ROS generation and cascade of events in detoxification. Critical Reviews in Oncology / Hematology 2017 116, 89-98DOI: (10.1016/j.critrevonc.2017.02.006) Copyright © 2017 Terms and Conditions

Fig. 2 Structural domains and their functions (A) KEAP1 (B) NRF2. Critical Reviews in Oncology / Hematology 2017 116, 89-98DOI: (10.1016/j.critrevonc.2017.02.006) Copyright © 2017 Terms and Conditions

Fig. 3 Stepwise mechanism of Keap1 mediated protection and repression during stressed and unstressed condition. Critical Reviews in Oncology / Hematology 2017 116, 89-98DOI: (10.1016/j.critrevonc.2017.02.006) Copyright © 2017 Terms and Conditions

Fig. 4 Various Mutations in different domains of Keap1 available at CBIO Portal. Critical Reviews in Oncology / Hematology 2017 116, 89-98DOI: (10.1016/j.critrevonc.2017.02.006) Copyright © 2017 Terms and Conditions