Simultaneous positron emission tomography (PET) assessment of metabolism with 18F- fluoro-2-deoxy-d-glucose (FDG), proliferation with 18F-fluoro-thymidine.

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Presentation transcript:

Simultaneous positron emission tomography (PET) assessment of metabolism with 18F- fluoro-2-deoxy-d-glucose (FDG), proliferation with 18F-fluoro-thymidine (FLT), and hypoxia with 18fluoro-misonidazole (F-miso) before and during radiotherapy in patients with non-small-cell lung cancer (NSCLC): A pilot study Pierre Vera, Pierre Bohn, Agathe Edet-Sanson, Alice Salles, Sebastien Hapdey, Isabelle Gardin, Jean-François Ménard, Romain Modzelewski, Luc Thiberville, Bernard Dubray Radiotherapy and Oncology Volume 98, Issue 1, Pages 109-116 (January 2011) DOI: 10.1016/j.radonc.2010.10.011 Copyright © 2010 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Actual schedule for the five evaluable patients. Radiotherapy and Oncology 2011 98, 109-116DOI: (10.1016/j.radonc.2010.10.011) Copyright © 2010 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 SUVmax for FLT, FDG, and F-miso before and during radiotherapy (RT) for 4 tumours and 12 nodes. Symbols represent the mean SUVmax. Error bars are 2× the standard error of the mean (SEM). Radiotherapy and Oncology 2011 98, 109-116DOI: (10.1016/j.radonc.2010.10.011) Copyright © 2010 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Correlations between the tracers’ uptakes. Radiotherapy and Oncology 2011 98, 109-116DOI: (10.1016/j.radonc.2010.10.011) Copyright © 2010 Elsevier Ireland Ltd Terms and Conditions

Fig. 4 Example of patient #003. Patient having 1 primary tumor and 4 mediastinal nodes [1 node is not presented at 46Gy (superimposition)]. Radiotherapy and Oncology 2011 98, 109-116DOI: (10.1016/j.radonc.2010.10.011) Copyright © 2010 Elsevier Ireland Ltd Terms and Conditions