Clinical Breast Cancer

Slides:



Advertisements
Similar presentations
Latent Bone Metastasis in Breast Cancer Tied to Src-Dependent Survival Signals Xiang H.-F. Zhang, Qiongqing Wang, William Gerald, Clifford A. Hudis, Larry.
Advertisements

Origins of Metastatic Traits Sakari Vanharanta, Joan Massagué Cancer Cell Volume 24, Issue 4, Pages (October 2013) DOI: /j.ccr
Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells Nilay Sethi, Xudong Dai, Christopher.
C/EBPβ at the core of the TGFβ cytostatic response and its evasion in metastatic breast cancer cells Roger R. Gomis, Claudio Alarcón, Cristina Nadal, Catherine.
Lung Adenocarcinoma with Ipsilateral Breast Metastasis: A Simple Coincidence? Hsu-Ching Huang, MD, Jen-Fan Hang, MD, Mei-Han Wu, MD, Teh-Ying Chou, MD,
Predictive Biomarker Profiling of > 6000 Breast Cancer Patients Shows Heterogeneity in TNBC, With Treatment Implications Sherri Z. Millis, Zoran Gatalica,
Design and Multiseries Validation of a Web-Based Gene Expression Assay for Predicting Breast Cancer Recurrence and Patient Survival Ryan K. Van Laar The.
Fuhrman Grade and Neutrophil-To-Lymphocyte Ratio Influence on Survival in Patients With Metastatic Renal Cell Carcinoma Treated With First-Line Tyrosine.
A2-06: Survival differences for non-Bronchioloalveolar Carcinoma (BAC) non-small-cell lung cancer (NSCLC) cases with ipsilateral intrapulmonary metastasis.
Case series of 21 patients with extrahepatic metastatic lobular breast carcinoma to the gastrointestinal tract  Noah Switzer, Andrew Lim, Lillian Du,
Prospective Study of the Effect of the 21-Gene Assay on Adjuvant Clinical Decision- Making in Japanese Women With Estrogen Receptor-Positive, Node-Negative,
Expression Levels of KMT2C and SLC20A1 Identified by Information-theoretical Analysis Are Powerful Prognostic Biomarkers in Estrogen Receptor-positive.
Significance of Fine Needle Aspiration Cytology and Vacuum-Assisted Core Needle Biopsy for Small Breast Lesions  Satoko Nakano, Masahiko Otsuka, Akemi.
Thierry Delaunoit, Paul J. Limburg, Richard M. Goldberg, James F
Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy in Patients With an Initial Diagnosis of Cytology-Proven Lymph Node-Positive Breast Cancer 
Efficacy and toxicity of rectal cancer reirradiation using IMRT for patients who have received prior pelvic radiation therapy  Fady F. Youssef, MS, Parag.
Activity of trastuzumab-emtansine (TDM1) in HER2-positive breast cancer brain metastases: A case series  Kevin C. Keith, Yueh Lee, Matthew G. Ewend, Timothy.
Maximizing the Benefit-Cost Ratio of Anthracyclines in Metastatic Breast Cancer: Case Report of a Patient with a Complete Response to High-Dose Doxorubicin.
Volume 195, Issue 5, Pages (May 2016)
Progressive brain metastases in an EGFR mutated adenocarcinoma of the lung: Response to gefitinib after progression on erlotinib  C. Leitner, R. von Moos,
Physical Effects of Unilateral Mastectomy on Spine Deformity
P. Therasse, S. Carbonnelle, J. Bogaerts 
Differences in Primary Care Clinicians' Approach to Non-small Cell Lung Cancer Patients Compared with Breast Cancer  Timothy R. Wassenaar, MD, Jens C.
A Phase II Randomized Study of Lapatinib Combined With Capecitabine, Vinorelbine, or Gemcitabine in Patients With HER2-Positive Metastatic Breast Cancer.
A Solitary Bone Lesion in a Patient With Previous Breast Cancer and the Importance of Bone Biopsy: A Case Report and a Review of Guidelines  Gaia Schiavon,
A. Gupta, K. Shridhar, P.K. Dhillon  European Journal of Cancer 
PUBLISH ONLY Journal of Thoracic Oncology
سرطان الثدي Breast Cancer
The use of high-dose cyclophosphamide, carmustine, and thiotepa plus autologous hematopoietic stem cell transplantation as consolidation therapy for high-risk.
Advances in the Treatment of Metastatic Prostate Cancer
Metastasis gets site specific
Program Goals. Single vs Dual HER2 Blockade for Metastatic HER2-Positive Breast Cancer.
Laurent Boccon-Gibod  European Urology Supplements 
Julia A. Files, MD, Marcia G. Ko, MD, Sandhya Pruthi, MD 
Fungating malignant phyllodes tumor
Susan C. Scott, MD, Nathan A. Pennell, MD, PhD 
Human epidermal growth factor receptor 2 borderline mortality in breast cancer patients: Evidence from surveillance, epidemiology, and end results program.
Role of radiotherapy in extracranial metastatic malignant melanoma in the modern era  Ryan S. Youland, Miran L. Blanchard, Roxanna Dronca, Lisa Kottschade,
Adjuvant chemotherapy for rectal cancer – Authors' reply
The Road to Quality Improvement in HER2-Positive Breast Cancer
IA05.01 Lung Cancer Cases Journal of Thoracic Oncology
Case series of 21 patients with extrahepatic metastatic lobular breast carcinoma to the gastrointestinal tract  Noah Switzer, Andrew Lim, Lillian Du,
A Comparison of Two Stereotactic Body Radiation Fractionation Schedules for Medically Inoperable Stage I Non-small Cell Lung Cancer: The Cleveland Clinic.
Heike Döppler, Peter Storz  Cell Metabolism 
Metastatic Breast Cancer Presenting as Esophageal Stricture
Targeting T Cell Co-receptors for Cancer Therapy
Differences in Primary Care Clinicians' Approach to Non-small Cell Lung Cancer Patients Compared with Breast Cancer  Timothy R. Wassenaar, MD, Jens C.
Ezrin… a metastatic detERMinant?
Psychological response and survival in breast cancer
The 20-Yr Outcome in Patients with Well- or Moderately Differentiated Clinically Localized Prostate Cancer Diagnosed in the Pre-PSA Era: The Prognostic.
Photodynamic Therapy for Early Stage Central Type of Lung Cancer
Metastatic Breast Cancer
Lung Cancer: A Wily Genetic Opponent
Clinical Characteristics and Outcomes for Patients With Thymic Carcinoma: Evaluation of Masaoka Staging  Anya M. Litvak, MD, Kaitlin Woo, MS, Sara Hayes,
PUBLISH ONLY Journal of Thoracic Oncology
A nationwide survey of oncologists regarding treatment-related infertility and fertility preservation in female cancer patients  Eric J. Forman, M.D.,
Arlene Chan, Marc Buyse, Bin Yao  The Lancet Oncology 
Leptomeningeal Metastasis from Non-small Cell Lung Cancer: Survival and the Impact of Whole Brain Radiotherapy  Patrick G. Morris, MD, MSc, Anne S. Reiner,
Lymphovascular Invasion in Non–Small-Cell Lung Cancer: Implications for Staging and Adjuvant Therapy  Kristin A Higgins, MD, Junzo P Chino, MD, Neal Ready,
James Allison, Lisa J. Herrinton, Liyan Liu, Jenny Yu, James Lowder 
Temporal Trends in Initiation of Therapy With Tumor Necrosis Factor Antagonists for Patients With Inflammatory Bowel Disease: A Population-based Analysis 
Compound Uncommon EGFR Mutations in a Patient with Advanced NSCLC and Durable Response to Sequential EGFR Targeted Therapies  Mary Linton B Peters, MD,
A2-06: Survival differences for non-Bronchioloalveolar Carcinoma (BAC) non-small-cell lung cancer (NSCLC) cases with ipsilateral intrapulmonary metastasis.
In This Issue Molecular Therapy Volume 16, Issue 4, (April 2008)
Systemic Therapy, Clinical Outcomes, and Overall Survival in Locally Advanced or Metastatic Pulmonary Carcinoid: A Brief Report  Patrick M. Forde, MD,
International Thymic Malignancies Interest Group: A Way Forward
Large clinical databases for the study of lung cancer: Making up for the failure of randomized trials  Chi-Fu Jeffrey Yang, MD, Matthew G. Hartwig, MD,
Thierry Delaunoit, Paul J. Limburg, Richard M. Goldberg, James F
EN1 expression in breast cancer and clinical outcome.
Human epidermal growth factor receptor 2 borderline mortality in breast cancer patients: Evidence from surveillance, epidemiology, and end results program.
Presentation transcript:

Clinical Breast Cancer Changing Natural History of HER2–Positive Breast Cancer Metastatic to the Brain in the Era of New Targeted Therapies  Louisa A. Mounsey, Allison M. Deal, Kevin C. Keith, Julia M. Benbow, Shlomit S. Shachar, Timothy Zagar, E. Claire Dees, Lisa A. Carey, Matthew G. Ewend, Carey K. Anders  Clinical Breast Cancer  DOI: 10.1016/j.clbc.2017.07.017 Copyright © 2017 The Authors Terms and Conditions

Figure 1 Overall Survival From Initial Breast Cancer Diagnosis by Year of Diagnosis Clinical Breast Cancer DOI: (10.1016/j.clbc.2017.07.017) Copyright © 2017 The Authors Terms and Conditions

Figure 2 Time From Initial Breast Cancer Diagnosis to First Metastatic Diagnosis by Year of Diagnosis Clinical Breast Cancer DOI: (10.1016/j.clbc.2017.07.017) Copyright © 2017 The Authors Terms and Conditions

Figure 3 Time From First Metastatic Diagnosis to Breast Cancer Brain Metastasis Diagnosis by Year of Diagnosis Clinical Breast Cancer DOI: (10.1016/j.clbc.2017.07.017) Copyright © 2017 The Authors Terms and Conditions

Figure 4 Time to Breast Cancer Brain Metastasis Diagnosis From Initial Breast Cancer Diagnosis by Year of Diagnosis Clinical Breast Cancer DOI: (10.1016/j.clbc.2017.07.017) Copyright © 2017 The Authors Terms and Conditions

Figure 5 Overall Survival After Breast Cancer Brain Metastasis Diagnosis by Year of Diagnosis Clinical Breast Cancer DOI: (10.1016/j.clbc.2017.07.017) Copyright © 2017 The Authors Terms and Conditions

Figure 6 Overall Survival After Breast Cancer Brain Metastasis Diagnosis by Receipt of HER2–Targeted Therapy Clinical Breast Cancer DOI: (10.1016/j.clbc.2017.07.017) Copyright © 2017 The Authors Terms and Conditions