MULTIPLE DISTINCT ATROPHY PATTERNS FOUND IN GENETIC FRONTOTEMPORAL DEMENTIA USING SUBTYPE AND STAGE INFERENCE (SUSTAIN) Alexandra L. Young, Razvan Valentin.

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MULTIPLE DISTINCT ATROPHY PATTERNS FOUND IN GENETIC FRONTOTEMPORAL DEMENTIA USING SUBTYPE AND STAGE INFERENCE (SUSTAIN) Alexandra L. Young, Razvan Valentin Marinescu, Neil P. Oxtoby, Martina Bocchetta, David M. Cash, David L. Thomas, Katrina M. Dick, M. Jorge Cardoso, Sebastien Ourselin, John C. van Swieten, Barbara Borroni, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Caroline Graff, Fabrizio Tagliavini, Giovanni B. Frisoni, Robert Laforce, Elizabeth Finger, Alexandre Mendonca, Sandro Sorbi, Nick C. Fox, Jonathan M. Schott, Jonathan D. Rohrer, Daniel C. Alexander Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 13, Issue 7, Pages P65-P66 (July 2017) DOI: 10.1016/j.jalz.2017.06.2352 Copyright © 2017 Terms and Conditions

Subtype and Stage Inference (SuStaIn) modelling of GENFI dataset Subtype and Stage Inference (SuStaIn) modelling of GENFI dataset. Subfigures (A)-(D) show the progression pattern of each of the four subtypes estimated by SuStaIn. Each progression pattern consists of a sequence in which regional brain volumes in mutation carriers (affected and unaffected) reach different z-scores relative to non-carriers. The cumulative probability each region has reached a particular z-score is shown for different stages along the progression; the cumulative probability of a region going from a z-score of 0-sigma to 1-sigma ranges from 0 in white to 1 in red, the cumulative probability of a region going from a z-score of 1-sigma to 2-sigma ranges from 0 in red to 1 in magenta, and the cumulative probability of a region going from a z-score of 2-sigma to 3-sigma ranges from 0 in magenta to 1 in blue. The circle labelled 'A' indicates the asymmetry of the atrophy pattern (absolute value of the difference in volume between the left and right hemispheres divided by the total volume of the left and right hemispheres) at each stage for each subtype. CVS is the model cross- validation similarity: the average similarity of the subtype progression patterns across cross-validation folds, measured using the Bhattacharyya coefficient. The CVS ranges from 0 (no similarity) to 1 (maximum similarity). Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2017 13, P65-P66DOI: (10.1016/j.jalz.2017.06.2352) Copyright © 2017 Terms and Conditions

Probability affected mutation carriers in GENFI belong to each of the four subtypes in Figure1. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2017 13, P65-P66DOI: (10.1016/j.jalz.2017.06.2352) Copyright © 2017 Terms and Conditions