Prescription and illicit psychoactive drugs in oral fluid—LC–MS/MS method development and analysis of samples from Brazilian drivers Ivomar Zancanaro,

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Prescription and illicit psychoactive drugs in oral fluid—LC–MS/MS method development and analysis of samples from Brazilian drivers Ivomar Zancanaro, Renata Pereira Limberger, Paula O. Bohel, Maíra Kerpel dos Santos, Raquel B. De Boni, Flavio Pechansky, Eloisa Dutra Caldas Forensic Science International Volume 223, Issue 1, Pages 208-216 (November 2012) DOI: 10.1016/j.forsciint.2012.08.048 Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 LC–MS/MS ions chromatograms of a blank oral fluid sample extract spiked at concentration of 0.5ng/mL. MBDB, n-metyl-1-(1,3-benzodioxol-5-il)-2-butanamine; m-CPP, 1-(3-chlorophenyl)piperazine; MDA, 3,4-methylenedioxy amphetamine; MDEA, methylene dioxyethylamphetamine; MDMA, 3,4-methylene dioxymethamphetamine; THC, tetrahydrocannabinol; BZE, benzoylecgonine; and EME, ecgonine methyl-ester. Forensic Science International 2012 223, 208-216DOI: (10.1016/j.forsciint.2012.08.048) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Matrix effect of PADs and metabolites in oral fluid, in % suppression or enhancement related to the solvent standard solution (mean, n=6). AMP, amphetamine; ALP, alprazolam; BZE, benzoylecgonine; BZP, bromazepam; CAN, canabinol; CLO, clonazepam; COC, cocaine; COD, codeine; DZP, diazepam; DIE, diethylpropion; EME, ecgonine methyl-ester; FEM, femproporex; FLU, flunitrazepam; HER, heroin; KET, ketamine; LRZ, lorazepam; MBDB, n-metyl-1-(1,3-benzodioxol-5-il)-2-butanamine; m-CPP, 1-(3-chlorophenyl)piperazine; MDA, 3,4-methylenedioxy amphetamine; MDEA, methylene dioxyethylamphetamine; MDMA, 3,4-methylene dioxymethamphetamine; METH, methamphetamine; MDN, methadone; MPH, methylphenidate; MOR, morphine; MID, midazolam; NZP, nitrazepam; NOR, nordiazepam; OXA, oxazepam; TZP, temazepam; THC, tetrahydrocannabinol; and TRA, tramadol. Forensic Science International 2012 223, 208-216DOI: (10.1016/j.forsciint.2012.08.048) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Ion suppession for THC at 17min retention time (upper insert in solvent and lower insert in matrix). Forensic Science International 2012 223, 208-216DOI: (10.1016/j.forsciint.2012.08.048) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 4 Stability of the processed sample extract at 16ng/mL, calculated as a percentage of the peak area response remaining after 0, 24, 36, 56 and 68h of extraction (n=3 each time). Forensic Science International 2012 223, 208-216DOI: (10.1016/j.forsciint.2012.08.048) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions