Biosynthesis and metabolism of testosterone

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Biosynthesis and metabolism of testosterone Biosynthesis and metabolism of testosterone. Heavy arrows indicate major pathways. Circled numbers represent enzymes as follows: cytochrome P450, family 11, subfamily A, polypeptide 1 (CYP11A1); hydroxy-Δ-5-steroid dehydrogenase, 3β- and steroid Δ-isomerase (HSD3β); 17α-hydroxylase activity of cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP17A1); 17,20-lyase activity of cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP17A1); hydroxysteroid (17β) dehydrogenase (HSD17β); steroid-5α- reductase, polypeptide 2 (3-oxo-5α-steroid Δ4-dehydrogenase α) (SRD5A); cytochrome P450, family 19, subfamily A, polypeptide 1 (CYP19A1). (Modified and redrawn, with permission, from Gardner DG et al. Greenspan’s Basic and Clinical Endocrinology, 9th ed. McGraw Hill, 2011.) Source: Disorders of the Male Reproductive Tract, Pathophysiology of Disease: An Introduction to Clinical Medicine, 7e Citation: Hammer GD, McPhee SJ. Pathophysiology of Disease: An Introduction to Clinical Medicine, 7e; 2013 Available at: https://accesspharmacy.mhmedical.com/DownloadImage.aspx?image=/data/Books/961/Ham007_Fig_23-04_001.gif&sec=53634129&BookID=961&ChapterSecID=53555704&imagename= Accessed: October 31, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved