Drug–polymer interaction and its significance on the physical stability of nifedipine amorphous dispersion in microparticles of an ammonio methacrylate.

Slides:

Advertisements

Similar presentations

Physical Pharmacy 2 1 KAUSAR AHMAD KULLIYYAH OF PHARMACY, IIUM THERMAL TRANSITION OF POLYMERS.

Advertisements

Crystallinity in Polymers

A part of Sustainable recycling of “green” plastics project Recycling of bio/petro blends.

An investigation into the stability and solubility of amorphous solid dispersion of BCS class II drugs Shrawan Baghel, WIT.

Effects of Milk Powders in Milk Chocolate B. Liang, R.W. Hartel Journal of Dairy Science Volume 87, Issue 1, Pages (January 2004) DOI: /jds.S (04)

Characterization of the interaction between Lomefloxacin and Certain Gastro-retentive Polymers Amir Ibrahim Mohamed a, Osama A. A. Ahmed b, Amira Osama.

Direct Measurements of the Mechanical Stability of Zinc-Thiolate Bonds in Rubredoxin by Single-Molecule Atomic Force Microscopy Peng Zheng, Hongbin Li.

Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism ‐ Based Prediction of Volume of Distribution Patrick Poulin, Frank ‐ Peter Theil.

Solvent-Mediated Solid Phase Transformations of cArbamazepine: Effects of Simulated Intestinal Fluid and Fasted State Simulated Intestinal Fluid Paula.

In Vivo Evaluation of 5-Fluorouracil-Containing Self-Expandable Nitinol Stent in Rabbits: Efficiency in Long-Term Local Drug Delivery Sheng-Rong Guo,

The Influence of Mechanical Processing of Dry Powder Inhaler Carriers on Drug Aerosolization Performance Paul M. Young, Hak-kim Chan, Herbert Chiou,

Optimization of Storage Stability of Lyophilized Actin Using Combinations of Disaccharides and Dextran S.Dean Allison, Mark C. Manning, Theodore W. Randolph,

Application of Powder X-ray Diffraction in Studying the Compaction Behavior of Bulk Pharmaceutical Powders Rebanta Bandyopadhyay, Jon Selbo, Gregory.

Evaluation of Indomethacin Percutaneous Absorption from Nanostructured Lipid Carriers (NLC): In Vitro and In Vivo Studies Maurizio Ricci, Carmelo Puglia,

Preparation of budesonide/γ‐cyclodextrin complexes in supercritical fluids with a novel SEDS method Tarja Toropainen, Sitaram Velaga, Teemu Heikkilä,

Stabilization of Lysozyme by Benzyl Alcohol: Surface Tension and Thermodynamic Parameters Monu Kumari Goyal, Ipsita Roy, Aeshna Amin, Uttam Chand Banerjee,

Preparation of budesonide/γ‐cyclodextrin complexes in supercritical fluids with a novel SEDS method Tarja Toropainen, Sitaram Velaga, Teemu Heikkilä,

Stabilization of Low Glass Transition Temperature Indomethacin Formulations: Impact of Polymer-Type and Its Concentration Rina J. Chokshi, Navnit H.

New Technology for the Investigation of Water Vapor Sorption–Induced Crystallographic Form Transformations of Chemical Compounds: A Water Vapor Sorption.

Comparison of a Miniaturized Shake-Flask Solubility Method with Automated Potentiometric Acid/Base Titrations and Calculated Solubilities A. Glomme,

Pediatric Drugs-A Review of Commercially Available Oral Formulations

In Vitro and In Vivo Evaluation of a Sulfenamide Prodrug of Basic Metformin Kristiina M. Huttunen, Jukka Leppänen, Jouko Vepsäläinen, Jouni Sirviö, Krista.

In Situ Measurement of Solvent-Mediated Phase Transformations During Dissolution Testing Jaakko Aaltonen, Paula Heinänen, Leena Peltonen, Hanna Kortejärvi,

G. Della Porta, N. Falco, E. Reverchon

Adsorption and function of recombinant Factor VIII at the air–water interface in the presence of Tween 80 Omkar Joshi, Liping Chu, Joseph McGuire, D.Q.

Design, Characterization, and Aerosol Dispersion Performance Modeling of Advanced Co-Spray Dried Antibiotics with Mannitol as Respirable Microparticles/Nanoparticles.

Solid-State Chemistry of Ambroxol Theophylline-7-Acetate

Ivermectin Interacts With Human ABCG2

Combined 4D‐Fingerprint and Clustering Based Membrane‐Interaction QSAR Analyses for Constructing Consensus Caco‐2 Cell Permeation Virtual Screens Osvaldo.

Synthesis and in vitro characterization of drug conjugates of l-carnitine as potential prodrugs that target human Octn2 Lei Diao, James E. Polli Journal.

Lubricant-Induced Crystallization of Itraconazole From Tablets Made of Electrospun Amorphous Solid Dispersion Balázs Démuth, Attila Farkas, Attila Balogh,

Hydrodynamic Effects on Drug Dissolution and Deaggregation in the Small Intestine—A Study with Felodipine as a Model Drug Lennart Lindfors, Malin Jonsson,

Silicon-dioxide−polyvinylpyrrolidone as a wound dressing for skin defects in a murine model Ferenc Öri, Richard Dietrich, Cornelia Ganz, Michael Dau,

Formulation of 3D Printed Tablet for Rapid Drug Release by Fused Deposition Modeling: Screening Polymers for Drug Release, Drug-Polymer Miscibility and.

Yongsheng Yang, Adil Mohammad, Robert T

Amorphous Solid Dispersion of Meloxicam Enhanced Oral Absorption in Rats With Impaired Gastric Motility Hiroki Suzuki, Keisuke Yakushiji, Saori Matsunaga,

A Promising New Method to Estimate Drug-Polymer Solubility at Room Temperature Matthias Manne Knopp, Natasha Gannon, Ilona Porsch, Malte Bille Rask, Niels.

Shining a Light on Phase Separation in the Cell

Volume 97, Issue 5, Pages (September 2009)

Volume 107, Issue 10, Pages (November 2014)

Volume 96, Issue 12, Pages (June 2009)

On Photo-Stability of Oxybenzone

How to evaluate and predict the ecologic impact of antibiotics: the pharmaceutical industry view from research and development R. Bax Clinical Microbiology.

Adina Coroaba, Tudor Pinteala, Anca Chiriac, Anca E. Chiriac, Bogdan C

Phase Transitions in Biological Systems with Many Components

Terhi Maula, Md. Abdullah Al Sazzad, J. Peter Slotte

Christa Trandum, Peter Westh, Kent Jørgensen, Ole G. Mouritsen

Jamie M. Dettler, Robert Buscaglia, Vu H. Le, Edwin A. Lewis

Francois le Pelletier, Anne Janin Journal of Investigative Dermatology

Minutes of the Board of Directors Meeting

Journal of Investigative Dermatology

Alessandro Paciaroni, Stefania Cinelli, Giuseppe Onori

Table of contents The Journal for Nurse Practitioners

Society for Investigative Dermatology 2010 Meeting Minutes

Volume 94, Issue 11, Pages (June 2008)

Volume 80, Issue 3, Pages (March 2001)

Research Snippets Journal of Investigative Dermatology

Volume 80, Issue 5, Pages (May 2001)

Raman Spectroscopic Studies Showing the UV Stability of Oxybenzone

Arnoldus W.P. Vermeer, Willem Norde Biophysical Journal

Journal of Investigative Dermatology

This Month in AJKD American Journal of Kidney Diseases

Quiz page answers August 2003

Quiz Page June 2009 American Journal of Kidney Diseases

Consequences of Psychological Distress in Adolescents with Acne

Journal of Investigative Dermatology

Quiz Page January 2010 American Journal of Kidney Diseases

Quiz page December 2003 American Journal of Kidney Diseases

Volume 80, Issue 3, Pages (March 2001)

The Size Distribution of Homozygous Segments in the Human Genome

Presentation transcript:

Drug–polymer interaction and its significance on the physical stability of nifedipine amorphous dispersion in microparticles of an ammonio methacrylate copolymer and ethylcellulose binary blend Jingjun Huang, Rodney J. Wigent, Joseph B. Schwartz Journal of Pharmaceutical Sciences Volume 97, Issue 1, Pages 251-262 (January 2008) DOI: 10.1002/jps.21072 Copyright © 2008 Wiley-Liss, Inc. Terms and Conditions

Figure 1 Nifedipine microparticles (RL/EC = 2:1 w/w) with 14% w/w of drug loading by polarized light microscopy (magnification: 40×). Scale bar equals to 20 µm. Journal of Pharmaceutical Sciences 2008 97, 251-262DOI: (10.1002/jps.21072) Copyright © 2008 Wiley-Liss, Inc. Terms and Conditions

Figure 2 Evaluation of microparticle crystallinity by X‐ray powder diffraction. EC, untreated ethylcellulose N7 powder; RL, untreated Eudragit RL powder; %, drug loading (w/w), NIF, crystalline nifedipine. Journal of Pharmaceutical Sciences 2008 97, 251-262DOI: (10.1002/jps.21072) Copyright © 2008 Wiley-Liss, Inc. Terms and Conditions

Figure 3 DSC thermal analysis of nifedipine of different physical forms. ANIF, amorphous nifedipine; NIF, crystalline nifedipine; NIF + plain microparticles, the physical mixture of plain microparticles with 10% w/w of crystalline nifedipine. Journal of Pharmaceutical Sciences 2008 97, 251-262DOI: (10.1002/jps.21072) Copyright © 2008 Wiley-Liss, Inc. Terms and Conditions

Figure 4 DSC thermal analysis of nifedipine microparticles with different drug loadings. (A) DSC thermograms of microparticles. (B) Phase diagrams of microparticles estimated from the DSC thermal analysis; solid line in the phase diagrams (B) represents the glass transition point (Tg) of drug–polymer solid solution predicted by the Gordon–Taylor equation (Eq. (1)); ANIF, amorphous nifedipine; NIF, crystalline nifedipine; Tm1, melting temperature of solid nifedipine domains in microparticles; Tm2, melting temperature of crystalline nifedipine outside of microparticles. Journal of Pharmaceutical Sciences 2008 97, 251-262DOI: (10.1002/jps.21072) Copyright © 2008 Wiley-Liss, Inc. Terms and Conditions

Figure 5 Chemical structure and proposed hydrogen‐bonding sites between (A) nifedipine and nifedipine; (B) Eudragit RL (R1=CH3, H; R2=CH3, CH2CH3; R3=CH2CH2N+(CH3)4Cl−; R2:R3 ≅ 3:0.2 mole/mole) and nifedipine; (C) ethylcellulose and nifedipine; ‐‐‐ represents hydrogen bonding between functional groups. Journal of Pharmaceutical Sciences 2008 97, 251-262DOI: (10.1002/jps.21072) Copyright © 2008 Wiley-Liss, Inc. Terms and Conditions

Figure 6 Investigation of drug–polymer interactions by FTIR. (A) Microparticles of nifedipine solid dispersion with an EC and RL binary blend (RL/EC = 2:1) at different drug loadings. (B) Solid dispersion of nifedipine with a single polymer RL or EC (10% w/w). NIF, crystalline nifedipine; ANIF, amorphous nifedipine; NIFRL, solid dispersion of nifedipine with RL; NIFEC, solid dispersion of nifedipine with EC; EC, untreated ethylcellulose N7; RL, untreated Eudragit RL. Journal of Pharmaceutical Sciences 2008 97, 251-262DOI: (10.1002/jps.21072) Copyright © 2008 Wiley-Liss, Inc. Terms and Conditions

Figure 7 FTIR spectra of nifedipine amorphous dispersion with RL or EC (10% w/w) in a closed container after 3‐month stability storage at 40°C/75% relative humidity. NIFRL, nifedipine solid dispersion with RL; NIFEC, nifedipine solid dispersion with EC. Journal of Pharmaceutical Sciences 2008 97, 251-262DOI: (10.1002/jps.21072) Copyright © 2008 Wiley-Liss, Inc. Terms and Conditions