Mendel & the gene idea Fig. 14-1

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Mendel & the gene idea Fig. 14-1 Figure 14.1 What principles of inheritance did Gregor Mendel discover by breeding garden pea plants?

Overview: Drawing from the Deck of Genes What genetic principles account for the passing of traits from parents to offspring? The “blending” hypothesis is the idea that genetic material from the two parents blends together (like blue and yellow paint blend to make green) Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

The “particulate” hypothesis is the idea that parents pass on discrete heritable units (genes) Mendel documented a particulate mechanism through his experiments with garden peas Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Concept 14.1: Mendel used the scientific approach to identify two laws of inheritance Mendel discovered the basic principles of heredity by breeding garden peas in carefully planned experiments Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

TECHNIQUE Parental generation (P) Stamens Carpel 1 2 3 4 Fig. 14-2a Figure14.2 Crossing pea plants Carpel 3 4

RESULTS First filial gener- ation offspring (F1) 5 Fig. 14-2b Figure14.2 Crossing pea plants

Mendel chose to track only those characters that varied in an either-or manner He also used varieties that were true-breeding (pure strains) meaning that plants produce offspring of the same variety when they self-pollinate) Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

The true-breeding parents are the P generation In a typical experiment, Mendel mated two contrasting, true-breeding varieties, a process called hybridization The true-breeding parents are the P generation The hybrid offspring of the P generation are called the F1 generation When F1 individuals self-pollinate, the F2 generation is produced Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

EXPERIMENT P Generation (true-breeding parents) Purple flowers White Fig. 14-3-1 EXPERIMENT P Generation (true-breeding parents)  Purple flowers White flowers Figure 14.3 When F1 hybrid pea plants are allowed to self-pollinate, which traits appear in the F2 generation?

EXPERIMENT P Generation (true-breeding parents) Purple flowers White Fig. 14-3-2 EXPERIMENT P Generation (true-breeding parents)  Purple flowers White flowers F1 Generation (hybrids) All plants had purple flowers Figure 14.3 When F1 hybrid pea plants are allowed to self-pollinate, which traits appear in the F2 generation?

EXPERIMENT P Generation (true-breeding parents) Purple flowers White Fig. 14-3-3 EXPERIMENT P Generation (true-breeding parents)  Purple flowers White flowers F1 Generation (hybrids) All plants had purple flowers Figure 14.3 When F1 hybrid pea plants are allowed to self-pollinate, which traits appear in the F2 generation? F2 Generation 705 purple-flowered plants 224 white-flowered plants

What Mendel called a “heritable factor” is what we now call a gene Mendel reasoned that only the purple flower factor was affecting flower color in the F1 hybrids Mendel called the purple flower color a dominant trait and the white flower color a recessive trait Mendel observed the same pattern of inheritance in six other pea plant characters, each represented by two traits What Mendel called a “heritable factor” is what we now call a gene Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Table 14-1

Mendel’s Model Mendel developed a hypothesis to explain the 3:1 inheritance pattern he observed in F2 offspring Four related concepts make up this model These concepts can be related to what we now know about genes and chromosomes Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Principle of Dominance Fig. 14-4 Principle of Dominance Allele for purple flowers Homologous pair of chromosomes Locus for flower-color gene Figure 14.4 Alleles, alternative versions of a gene Allele for white flowers Allele is an alternate version of a gene – & ea. indiv. Inherits an allele from ea. parent

P Generation Appearance: Purple flowers White flowers Genetic makeup: Fig. 14-5-1 P Generation Appearance: Purple flowers White flowers Genetic makeup: PP pp Gametes: P p Figure 14.5 Mendel’s law of segregation

P Generation Appearance: Purple flowers White flowers Genetic makeup: Fig. 14-5-2 P Generation Appearance: Purple flowers White flowers Genetic makeup: PP pp Gametes: P p F1 Generation Appearance: Purple flowers Genetic makeup: Pp Gametes: 1/2 P 1/2 p Figure 14.5 Mendel’s law of segregation

Law of Segregation P Generation Appearance: Purple flowers Fig. 14-5-3 P Generation Appearance: Purple flowers White flowers Genetic makeup: PP pp Gametes: P p F1 Generation Appearance: Law of Segregation Purple flowers Genetic makeup: Pp Gametes: 1/2 P 1/2 p Sperm Figure 14.5 Mendel’s law of segregation F2 Generation P p P PP Pp Eggs p Pp pp 3 1

Useful Genetic Vocabulary An organism with two identical alleles for a character is said to be homozygous for the gene controlling that character An organism that has two different alleles for a gene is said to be heterozygous for the gene controlling that character Unlike homozygotes, heterozygotes are not true- breeding Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Because of the different effects of dominant and recessive alleles, an organism’s traits do not always reveal its genetic composition Therefore, we distinguish between an organism’s phenotype, or physical appearance, and its genotype, or genetic makeup In the example of flower color in pea plants, PP and Pp plants have the same phenotype (purple) but different genotypes Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Phenotype Genotype PP Purple 1 (homozygous) 3 Purple Pp (heterozygous) Fig. 14-6 Phenotype Genotype PP Purple 1 (homozygous) 3 Purple Pp (heterozygous) 2 Purple Pp (heterozygous) Figure 14.6 Phenotype versus genotype pp 1 White 1 (homozygous) Ratio 3:1 Ratio 1:2:1

The Testcross How can we tell the genotype of an individual with the dominant phenotype? Such an individual must have one dominant allele, but the individual could be either homozygous dominant or heterozygous The answer is to carry out a testcross: breeding the mystery individual with a homozygous recessive individual If any offspring display the recessive phenotype, the mystery parent must be heterozygous Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Test cross TECHNIQUE RESULTS Dominant phenotype, unknown genotype: Fig. 14-7 TECHNIQUE  Test cross Dominant phenotype, unknown genotype: PP or Pp? Recessive phenotype, known genotype: pp Predictions If PP If Pp or Sperm Sperm p p p p P P Pp Pp Pp Pp Eggs Eggs Figure 14.7 The testcross P p Pp Pp pp pp RESULTS or All offspring purple 1/2 offspring purple and 1/2 offspring white

Test cross TECHNIQUE Dominant phenotype, unknown genotype: PP or Pp? Fig. 14-7a TECHNIQUE Test cross  Dominant phenotype, unknown genotype: PP or Pp? Recessive phenotype, known genotype: pp Predictions If PP If Pp or Sperm Sperm p p p p Figure 14.7 The testcross P P Pp Pp Pp Pp Eggs Eggs P p Pp Pp pp pp

Test cross RESULTS or All offspring purple 1/2 offspring purple and Fig. 14-7b Test cross RESULTS or All offspring purple 1/2 offspring purple and 1/2 offspring white Figure 14.7 The testcross

The Law of Independent Assortment Mendel derived the law of segregation by following a single character The F1 offspring produced in this cross were monohybrids, individuals that are heterozygous for one character A cross between such heterozygotes is called a monohybrid cross But what happened when 2 traits were observed? Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

RESULTS Phenotypic ratio approximately 9:3:3:1 Fig. 14-8b 315 108 101 32 Phenotypic ratio approximately 9:3:3:1 Figure 14.8 Do the alleles for one character assort into gametes dependently or independently of the alleles for a different character?

Using a dihybrid cross, Mendel developed the law of independent assortment The law of independent assortment states that each pair of alleles segregates independently of each other pair of alleles during gamete formation Strictly speaking, this law applies only to genes on different, nonhomologous chromosomes Genes located near each other on the same chromosome tend to be inherited together Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings