A Promising Therapy for stroke

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A Promising Therapy for stroke CELL THERAPY A Promising Therapy for stroke NIE CONG 11307120244 24TH MAR. 2014

Two Kinds of Cells for the Therapy Olle Lindvall, Zaal Kokaia. Stem Cell Research in Stroke: How Far From the Clinic? [J]STROKE. 2011;42:2369-2375.

Hypothesis Ⅰ Neural stem cells would replace lost neurons and circuits

Proof: Limitations: Documented synaptic integration Dysfunction of newly formed neurons Poor survival of the cells Risk of tumor formation

Hypothesis Ⅱ potentially be induced by stimulating Recovery after stroke could potentially be induced by stimulating endogenous neurogenesis

To stimulate the proliferation of NSCs Background: NSCs’ proliferation after stroke Goal: To stimulate the proliferation of NSCs To keep the new neurons alive Cells: Hematopoietic stem cells (mesenchymal stem cells, BMSCs) mesenchymal stem cells, MSCs

Non-NSCs’ Ability to Enhance Intrinsic Repair Y. Li, J. Chen, X.G. Chen. Human marrow stromal cell therapy for stroke in rat: Neurotrophins and functional recovery.[J] NEUROLOGY 2002;59:514–523

REFERENCE: Olle Lindvall, Zaal Kokaia. Stem Cell Research in Stroke: How Far From the Clinic? [J]STROKE. 2011;42:2369-2375. Y. Li, J. Chen, X.G. Chen. Human marrow stromal cell therapy for stroke in rat: Neurotrophins and functional recovery.[J] NEUROLOGY 2002;59:514–523 . Robin Lemmensa, Gary K. Steinberg. Stem cell therapy for acute cerebral injury: whatdo we know and what will the future bring?[J] Curr Opin Neurol 2013, 26:617–625. Sebastian Haas, Norbert Weidner . Jurgen Winkler. Adult stem cell therapy in stroke.[J] Curr Opin Neurol 2005,18:59–64. Cesar V. Borlongan. Cell Therapy for Stroke: Remaining Issues to Address Before Embarking on Clinical Trials.[J] Stroke. 2009;40[suppl 1]:S146-S148.) Yuan ZJ, Li XG. Stem cell therapy for ischemic stroke. Zhongguo Zuzhi Gongcheng Yanjiu. 2013;17(45):7954-7960.

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