Synergistically Induced Hypothermia and Enhanced Neuroprotection by Pharmacological and Physical Approaches in Stroke Zhang Jun 1 ;Liu Kaiyin 2 ;Elmadhoun.

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Synergistically Induced Hypothermia and Enhanced Neuroprotection by Pharmacological and Physical Approaches in Stroke Zhang Jun 1 ;Liu Kaiyin 2 ;Elmadhoun Omar 2 ;Ji Xunming 1 ;Duan Yunxia 1 ;Shi Jingfei 1 ; Xiaoduo He ; 1 , Xiangrong Liu ; 1 , Di Wu ; 1 , Ruiwen Che ; 1 , Xiaokun Geng 2,3 , Yuchuan Ding 1,2,3 ; Figure 4. Apoptotic protein expression evaluated by Western blotting. A Bax protein expression was significantly #cod#x0002A;#cod#x0002A;#cod#x0002A; p #cod#x0003C;0.001, #cod#x0002A; p #cod#x0003C;0.05 increased in no treatment group at 6 #cod#x0002A;#cod#x0002A;#cod#x0002A; p #cod#x0003C;0.001 and 24 h #cod#x0002A; p #cod#x0003C;0.05 compared with sham control artificially set at 1. At 6 h, the combination therapy significantly ### p #cod#x0003C;0.001 reduced protein expression. At 24 h, L-DHC group significantly ## p #cod#x0003C;0.01 reduced protein expression. This reduction was enhanced by combination therapy ## p #cod#x0003C;0.01. B Cleaved caspase-3 protein expression was significantly increased after stroke at 6 #cod#x0002A; p #cod#x0003C;0.05 and 24 h #cod#x0002A;#cod#x0002A; p #cod#x0003C;0.01 of reperfusion. The combination therapy significantly ### p #cod#x0003C;0.001 reduced protein expression at 6 h of reperfusion. At 24 h, the reduced effect of L-DHC on cleaved caspase-3 protein expression ### p #cod#x0003C;0.001, was significantly ### p #cod#x0003C;0.001 enhanced by combination therapy. C Bcl-2 protein expression was significantly reduced after stroke at both 6 ### p #cod#x0003C;0.001 and 24 ###p#cod#x0003C;0.001 h of reperfusion. L-DHC and ice pad significantly increased the protein expression at 6 #cod#x0002A; p #cod#x0003C;0.05, #cod#x0002A;#cod#x0002A;#cod#x0002A; p #cod#x0003C;0.001 and 24 h #cod#x0002A;#cod#x0002A;#cod#x0002A; p #cod#x0003C;0.001, #cod#x0002A;#cod#x0002A; p #cod#x0003C;0.01 of reperfusion. The combination therapy augmented the increase seen in L-DHC #cod#x0002A;#cod#x0002A;#cod#x0002A; p #cod#x0003C;0.001, #cod#x0002A;#cod#x0002A;#cod#x0002A; p #cod#x0003C;0.001 and ice pad groups #cod#x0002A;#cod#x0002A;#cod#x0002A; p #cod#x0003C;0.001, #cod#x0002A;#cod#x0002A;#cod#x0002A; p #cod#x0003C;0.001 at both time-points. D Bcl-xl protein expression was significantly reduced after stroke at the two-time points after reperfusion # p #cod#x0003C;0.05, #p#cod#x0003C;0.05. While L-DHC significant increased the protein expression at both time-points #cod#x0002A;#cod#x0002A;#cod#x0002A; p #cod#x0003C;0.001, #cod#x0002A;#cod#x0002A; p #cod#x0003C;0.01, the combination therapy enhanced the increase at 6 #cod#x0002A; p #cod#x0003C;0.05 and 24 #cod#x0002A; p #cod#x0003C;0.05 of reperfusion. null,null,0(0),null-null. Doi:10.14336/AD.2017.08167