Inn Lee, Lena Hinrichs, Rayaz A. Malik,

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Corneal Confocal Microscopy as surrogate marker in Inflammatory Neuropathies Inn Lee, Lena Hinrichs, Rayaz A. Malik, Christoph Kleinschnitz, Bernd C. Kieseier, and Mark Stettner EAN Amsterdam, 26. Juli 2017 Mark Stettner; MD, PhD Department of Neurology University Hospital Essen Germany

Corneal Confocal Microscopy rapid (2 min) non-invasive (in vivo) reiterative images corneal structures

Corneal Confocal Microscopy Stettner et al. 2015

Corneal Confocal Microscopy Patients with CIDP and MMN revealed a reduction in corneal nerve fiber (CNF) measures and an enlargement in corneal immune cell infiltrates. In CIDP, CNF parameters decreased with longer disease duration. The number of dendritic cells in proximity to corneal nerve fibers was increased in patients with early disease and correlated with the degree of motor affection. Cranial nerve affection was associated with increased corneal cell infiltrates. Neuritis activity correlated with the number of dendritic cells in proximity to CNF. In painful neuropathies a further reduction in CNF parameters and an increase in non-dendritic cells became apparent. In CIDP patients presenting with anti-neuronal antibodies the number of non-dendritic cells was increased. Stettner et al. 2015

Corneal Confocal Microscopy

Corneal Confocal Microscopy

Corneal Confocal Microscopy Considerable potential as a surrogate marker for CIDP Corneal nerve fiber loss may reflect severity of neuropathy Quantification of distinct cells around the CNF plexus may stratify CIDP subtypes, clinical course and disease activity