Modeling Hemodynamic Profiles by Telemetry in the Rat

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Modeling Hemodynamic Profiles by Telemetry in the Rat by Erminio Bonizzoni, Silvano Milani, Ennio Ongini, Carlo Casati, and Angela Monopoli Hypertension Volume 25(4):564-569 April 1, 1995 Copyright © American Heart Association, Inc. All rights reserved.

Graphs show 24-hour profiles of systolic blood pressure (SBP) and diastolic blood pressure (DBP) (top) and heart rate (bottom) as recorded in control spontaneously hypertensive rats for 3 consecutive days with the telemetry system. Graphs show 24-hour profiles of systolic blood pressure (SBP) and diastolic blood pressure (DBP) (top) and heart rate (bottom) as recorded in control spontaneously hypertensive rats for 3 consecutive days with the telemetry system. Data represent the mean response of six animals. Erminio Bonizzoni et al. Hypertension. 1995;25:564-569 Copyright © American Heart Association, Inc. All rights reserved.

Scatterplots show the change in systolic blood pressure (SBP) (a, b) and heart rate (HR) (c, d) 24-hour profiles induced by the A1 adenosine agonist 2-chloro-N6-cyclopentyladenosine at 0.03 mg/kg IP (a, c) and 0.3 mg/kg IP (b, d). Scatterplots show the change in systolic blood pressure (SBP) (a, b) and heart rate (HR) (c, d) 24-hour profiles induced by the A1 adenosine agonist 2-chloro-N6-cyclopentyladenosine at 0.03 mg/kg IP (a, c) and 0.3 mg/kg IP (b, d). The continuous line represents the mean constant curve of seven spontaneously hypertensive rats. ▴ represents the mean of residuals obtained as the difference between observed and predicted values of each hemodynamic profile. Erminio Bonizzoni et al. Hypertension. 1995;25:564-569 Copyright © American Heart Association, Inc. All rights reserved.

Scatterplots show the change in systolic blood pressure (SBP) (a, b) and heart rate (HR) (c, d) 24-hour profiles induced by the A2a adenosine agonist 2-hexynyl-5′-N-ethylcarboxamidoadenosine at 0.003 mg/kg IP (a, c) and 0.03 mg/kg IP (b, d). Scatterplots show the change in systolic blood pressure (SBP) (a, b) and heart rate (HR) (c, d) 24-hour profiles induced by the A2a adenosine agonist 2-hexynyl-5′-N-ethylcarboxamidoadenosine at 0.003 mg/kg IP (a, c) and 0.03 mg/kg IP (b, d). The continuous line represents the mean constant curve of seven spontaneously hypertensive rats. ▴ represents the mean of residuals obtained as the difference between observed and predicted values of each hemodynamic profile. Erminio Bonizzoni et al. Hypertension. 1995;25:564-569 Copyright © American Heart Association, Inc. All rights reserved.

Scatterplot shows the change in heart rate (HR) 24-hour profile induced by the nonselective adenosine agonist 5′-N-ethylcarboxamidoadenosine (0.1 mg/kg IP). Scatterplot shows the change in heart rate (HR) 24-hour profile induced by the nonselective adenosine agonist 5′-N-ethylcarboxamidoadenosine (0.1 mg/kg IP). The continuous line represents the mean constant curve of eight spontaneously hypertensive rats. ▴ represents the mean of residuals obtained as the difference between observed and predicted values of each individual hemodynamic profile. Erminio Bonizzoni et al. Hypertension. 1995;25:564-569 Copyright © American Heart Association, Inc. All rights reserved.