Synergistically Induced Hypothermia and Enhanced Neuroprotection by Pharmacological and Physical Approaches in Stroke Zhang Jun 1 ;Liu Kaiyin 2 ;Elmadhoun.

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Synergistically Induced Hypothermia and Enhanced Neuroprotection by Pharmacological and Physical Approaches in Stroke Zhang Jun 1 ;Liu Kaiyin 2 ;Elmadhoun Omar 2 ;Ji Xunming 1 ;Duan Yunxia 1 ;Shi Jingfei 1 ; Xiaoduo He ; 1 , Xiangrong Liu ; 1 , Di Wu ; 1 , Ruiwen Che ; 1 , Xiaokun Geng 2,3 , Yuchuan Ding 1,2,3 ; Figure 2. Neurological deficits and brain infarct volumes at 24 h of reperfusion. Higher scores represent greater deficits in neurological function in the 5-point A and 12-point scale B systems after stroke. At 24 h after reperfusion, slightly lower scores 3.3 #cod#x000B1; 0.7, 6.8 #cod#x000B1; 0.5 were observed in L-DHC group than no treatment group 4.3 #cod#x000B1; 0.3, 10.6 #cod#x000B1; 0.4 ##p#cod#x0003C;0.01, ###p#cod#x0003C;0.001. In the L-DHC with normal temperature 4.3#cod#x000B1;0.4, 10.6 #cod#x000B1; 0.3 ##p#cod#x0003C;0.01, ###p#cod#x0003C;0.001, these reductions were statistically reversed. The combination therapy largely reduced deficit score 2.4 #cod#x000B1; 0.5, 4.3 #cod#x000B1; 0.4 ###p#cod#x0003C;0.001, ###p#cod#x0003C;0.001 as compared with L-DHC and ice pad each alone. Neither ice pad 4.3 #cod#x000B1; 0.3, 9.4 #cod#x000B1; 0.3 nor H-DHC group 3.9#cod#x000B1;0.4, 9.1#cod#x000B1;0.5 showed significant therapeutic effects. C Representatives of brain slices with TTC staining after ischemiareperfusion in each group are shown. D At 24 h of reperfusion, the stroke group without treatment and L-DHC with normal temperature 37#cod#x000B0;C showed infarct volume of 49.5 #cod#x000B1; 12.4#cod#x00025; and 50.0 #cod#x000B1; 11.2#cod#x00025;, respectively. L-DHC significantly ##p#cod#x0003C;0.01 reduced infarct volume 36.7 #cod#x000B1; 9.9#cod#x00025;. The combination of L-DHC with ice pad further reduced infarct volume to 18.2 #cod#x000B1; 5.8#cod#x00025; ###p#cod#x0003C;0.001. Neither ice pad 47.9 #cod#x000B1; 10.3#cod#x00025; nor H-DHC 1.5mgkg 43.3 #cod#x000B1; 9.4#cod#x00025; alone showed a therapeutic effect. null,null,0(0),null-null. Doi:10.14336/AD.2017.08167