Stress and serotonin system David Chen 11307120002 Stress and serotonin system

What is serotonin? Neurotransmitter(神经递质) Also called 5-hydrotrptamine(5-HT)5-羟色胺 Synthesized from tryptphan

How does this system work? Fig. from Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease

Distribution of serotonergic neurons in our brain mPFC内侧前额叶 Amygdala杏仁体 DRN中缝背核 Fig. from Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease

Relation between serotonin and stress Exposure to stressors … serotonin neuron activity is increased… --Excerpted from Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus …at all levels of the serotonin system…can influence … the response to stress. --Excerpted from Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease

Compromised by chronic stress leading to ‘learned helplessness’（习得性无助） 5-HT1A-R Autoreceptor (自受体)on the soma and dendrites of serotonin cells --Excerpted from Immunohistochemical evidence of the existence of 5-HT1A autoreceptors on serotoninergic neurons in the midbrain raphe nuclei Whose activation inhibits DRN neuronal firing and consequent forebrain release --Excerpted from Direct Immunohistochemical evidence of the existence of 5-HT1A autoreceptors on serotoninergic neurons in the midbrain raphe nuclei. Compromised by chronic stress leading to ‘learned helplessness’（习得性无助） --excerpted from Learned helplessness

Method Forced swim test Tail suspension test Gene knockout Evaluation of antidepressants（抗抑郁药）… aimed at rendering or preventing depressive-like states --Excerpted from The mouse forced swim test. Tail suspension test Gene knockout

Reference [1] Sotelo C, Cholley B, El Mestikawy S, Gozlan H, Hamon M. Direct Immunohistochemical evidence of the existence of 5-HT1A autoreceptors on serotoninergic neurons in the midbrain raphe nuclei. EurJ Neurosci 1990;2:1144–1154. [2] Seligman ME. Learned helplessness. Annu Rev Med 1972;23:407–412 [3] C Adem et al. The Mouse Forced Swim Test J Vis Exp. 2012 Jan 29;(59):e3638 [4] Andrew Holmes Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease Neurosci Biobehav Rev. 2008 September ; 32(7): 1293–1314. doi:10.1016/j.neubiorev.2008.03.006. [5] Clifford EM, Gartside SE, Umbers V, Cowen PJ, Hajos M, Sharp T. Electrophysiological and neurochemical evidence that pindolol has agonist properties at the 5-HT1A autoreceptor in vivo. Br J Pharmacol 1998;124:206–212. [6] Amat J, Baratta MV, Paul E, Bland ST, Watkins LR, Maier SF. Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus. Nat Neurosci 2005;8:365–371

Any suggestions will be highly appreciated!