NEUROHUMORAL TRANSMISSION

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Presentation transcript:

NEUROHUMORAL TRANSMISSION PROF. A. K. SAKSENA

Neurohumoral Transmission SYNTHESIS :- Terminal/ Cyton Rate limiting step Precursor + synthesizing enzymes 2) STORAGE :- With ATP (as complex) Different granules – Ad Reserpine 3) CONDUCTION :- Polar membrane, Na+ channels (voltage gated) 4) RELEASE :- Ca++ (exocytosis)

Neurohumoral Transmission(contd.) 5) ACTION ON POST-SYN. RECEPTOR :- EPSP/IPSP- Ligand gated ion channels Secondary messengers ↑ IP3/DAG or ↑/↓cAMP 6) ACTION ON PRE–SYN. RECEPTOR:- a. Autoreceptors b. Heteroreceptors α2↓ , β2↑, m2 7) TERMINATION :- a) Two step reuptake b) Enzymes- ChE, MAO/COMT

NERVOUS SYSTEM

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