Swallowing sparing intensity modulated radiotherapy (SW-IMRT) in head and neck cancer: Clinical validation according to the model-based approach Miranda.

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Swallowing sparing intensity modulated radiotherapy (SW-IMRT) in head and neck cancer: Clinical validation according to the model-based approach Miranda E.M.C. Christianen, Arjen van der Schaaf, Hans Paul van der Laan, Irma M. Verdonck-de Leeuw, Patricia Doornaert, Olga Chouvalova, Roel J.H.M. Steenbakkers, Charles René Leemans, Sjoukje F. Oosting, Bernard F.A.M. van der Laan, Jan L.N. Roodenburg, Ben J. Slotman, Hendrik P. Bijl, Johannes A. Langendijk Radiotherapy and Oncology Volume 118, Issue 2, Pages 298-303 (February 2016) DOI: 10.1016/j.radonc.2015.11.009 Copyright © 2015 The Authors Terms and Conditions

Fig. 1 NTCP comparison plot. The plot shows the NTCP values for SW-IMRT as a function of the NTCP values for standard IMRT. All dots are below the black dashed line indicating that the NTCP values for SW-IMRT are generally lower than those obtained with standard IMRT. The blue squares indicate patients with ⩾ΔNTCP >5% and the red dots indicate patients with ΔNTCP 0–5%. Abbreviations: IMRT=intensity modulated radiotherapy, SW-IMRT=swallowing sparing IMRT, NTCP=normal tissue complication probability. Radiotherapy and Oncology 2016 118, 298-303DOI: (10.1016/j.radonc.2015.11.009) Copyright © 2015 The Authors Terms and Conditions

Fig. 2 Calibration plots for the previous cohort [7] treated with standard IMRT versus that for the current cohort treated with SW-IMRT. Abbreviations: IMRT=intensity modulated radiotherapy, SW-IMRT=swallowing sparing IMRT, NTCP=normal tissue complication probability. Radiotherapy and Oncology 2016 118, 298-303DOI: (10.1016/j.radonc.2015.11.009) Copyright © 2015 The Authors Terms and Conditions

Fig. 3 Observed prevalence after SW-IMRT (dark blue) compared to predicted NTCP values for SW-IMRT (light blue) and to predicted NTCP values for standard IMRT based on the back up standard IMRT plans (orange). The observed prevalences in all patients and in those in the HIGH ΔNTCP groups corresponded significantly better with the average NTCP values for SW-IMRT than with those for standard IMRT (red arrow). Abbreviations: IMRT=intensity modulated radiotherapy, SW-IMRT=swallowing sparing IMRT, NTCP=normal tissue complication probability. Radiotherapy and Oncology 2016 118, 298-303DOI: (10.1016/j.radonc.2015.11.009) Copyright © 2015 The Authors Terms and Conditions