Long-term efficacy and safety of vildagliptin add-on therapy in type 2 diabetes mellitus with insulin treatment Ippei Kanazawa, Ken-ichiro Tanaka, Masakazu.

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Long-term efficacy and safety of vildagliptin add-on therapy in type 2 diabetes mellitus with insulin treatment Ippei Kanazawa, Ken-ichiro Tanaka, Masakazu Notsu, Sayuri Tanaka, Nobuaki Kiyohara, Sayo Koike, Yuko Yamane, Yuko Tada, Motofumi Sasaki, Mika Yamauchi, Toshitsugu Sugimoto Diabetes Research and Clinical Practice Volume 123, Pages 9-17 (January 2017) DOI: 10.1016/j.diabres.2016.11.010 Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Patient disposition. Diabetes Research and Clinical Practice 2017 123, 9-17DOI: (10.1016/j.diabres.2016.11.010) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Unadjusted mean (±SE) changes in HbA1c. *p<0.05; **p<0.01; ***p<0.001 vs. baseline in each group. Diabetes Research and Clinical Practice 2017 123, 9-17DOI: (10.1016/j.diabres.2016.11.010) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Mean changes (±SE) in HbA1c from baseline to the last observation. **p<0.01 vs. control. Diabetes Research and Clinical Practice 2017 123, 9-17DOI: (10.1016/j.diabres.2016.11.010) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 4 Adjusted mean changes (±SE) in dose (A) and number (B) of insulin injections from baseline ***p<0.001 vs. baseline in each group. Diabetes Research and Clinical Practice 2017 123, 9-17DOI: (10.1016/j.diabres.2016.11.010) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 5 Mean changes (±SE) in dose and number of insulin injections from baseline to the last observation **p<0.01; ***p<0.001 vs. control. Diabetes Research and Clinical Practice 2017 123, 9-17DOI: (10.1016/j.diabres.2016.11.010) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 6 Mean changes (±SE) in dose of total, bolus, and basal insulin from baseline to the last observation. *p<0.05; **p<0.01 vs. control. Diabetes Research and Clinical Practice 2017 123, 9-17DOI: (10.1016/j.diabres.2016.11.010) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 7 Adjusted mean change (±SE) in body weight (A), ALT (B), and eGFR (C) from baseline. Diabetes Research and Clinical Practice 2017 123, 9-17DOI: (10.1016/j.diabres.2016.11.010) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions