From: Hepatocyte Growth Factor Induces Retinal Vascular Permeability via MAP-Kinase and PI-3 Kinase without Altering Retinal Hemodynamics Invest. Ophthalmol.

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From: Hepatocyte Growth Factor Induces Retinal Vascular Permeability via MAP-Kinase and PI-3 Kinase without Altering Retinal Hemodynamics Invest. Ophthalmol. Vis. Sci.. 2006;47(6):2701-2708. doi:10.1167/iovs.05-0071 Figure Legend: (A) HGF-induced retinal vascular permeability was partially mediated in vivo by PI-3 kinase and MAPK, but not by protein kinase C. The effect of a 10-minute pretreatment with PI-3 kinase inhibitor (LY294002 at 50 μM), MEK-specific inhibitor (PD98059 at 20 μM), or non-isoform-selective protein kinase C inhibitor (GFX at 0.5 μM) on vitreous fluorescein leakage after HGF injection (5 ng/eye) was evaluated. Pretreatment with BSA established the basal (100%) HGF/SF leakage stimulation level. (* P = 0.005; †P = 0.015 compared with eyes pretreated with BSA and injected with HGF.) (B) HGF/VEGF’s effect on retinal vascular permeability was not additive in vivo. The effect of a 10-minute pretreatment with PI-3 kinase inhibitor (LY294002 at 50 μM) or MEK-specific inhibitor (PD98059 at 20 μM) on vitreous fluorescein leakage after an HGF (5 ng/eye)/VEGF (2 ng/eye) combination injection was evaluated. Pretreatment with balanced saline established basal (100%) leakage stimulation level. (*P < 0.01 compared with eyes pretreated with balanced saline and injected with BSA.) Date of download: 11/1/2017 The Association for Research in Vision and Ophthalmology Copyright © 2017. All rights reserved.