Volume 101, Issue 6, Pages (June 2007)

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Volume 101, Issue 6, Pages 1205-1211 (June 2007) Protein kinase C inhibition attenuates hypochlorite-induced acute lung injury Stefan Hammerschmidt, Tobias Vogel, Susan Jockel, Christian Gessner, Hans-Jürgen Seyfarth, Adrian Gillissen, Hubert Wirtz Respiratory Medicine Volume 101, Issue 6, Pages 1205-1211 (June 2007) DOI: 10.1016/j.rmed.2006.11.003 Copyright © 2006 Elsevier Ltd Terms and Conditions

Figure 1 Time course of pulmonary artery pressure increase: Change in PAP (ΔPAP) over time in controls (upper panel, A) and HOCl treated lungs (lower panel, B). Control lungs without inhibitor are characterized by a square. Staurosporin (100nM) or BIM (10nM) treated lungs are characterized by circle (staurosporin) or triangle (BIM). *p<0.05 versus corresponding control; †p<0.05 versus HOCl group. Respiratory Medicine 2007 101, 1205-1211DOI: (10.1016/j.rmed.2006.11.003) Copyright © 2006 Elsevier Ltd Terms and Conditions

Figure 2 Mean experimental time: Experiments were terminated at 105min or when the increase in lung weight due to fluid retention exceeded 50g. This time is depicted as the mean experimental time for each group. *p<0.05 versus corresponding control; †p<0.05 versus HOCl group. Respiratory Medicine 2007 101, 1205-1211DOI: (10.1016/j.rmed.2006.11.003) Copyright © 2006 Elsevier Ltd Terms and Conditions

Figure 3 Baseline and maximum pulmonary artery pressure: Baseline PAP (black) and maximum PAP (white) of all experimental groups. *p<0.05 versus corresponding baseline PAP. Respiratory Medicine 2007 101, 1205-1211DOI: (10.1016/j.rmed.2006.11.003) Copyright © 2006 Elsevier Ltd Terms and Conditions

Figure 4 Vascular permeability: Fluid retention (ΔW, panels A and C) and capillary filtration coefficient (Kf,c expressed as 10−4mls−1cmH2O−1g−1, panels B and D) registered during hydrostatic challenges. Upper panels show controls (A and B), lower panels show HOCl experiments (C and D). Experiments without PKC inhibitor are characterized by a square. Experiments with staurosporin (100nM) or BIM (10nM) are characterized by circles (staurosporin) and triangles (BIM). *p<0.05 versus corresponding control; †p<0.05 versus HOCl group. Respiratory Medicine 2007 101, 1205-1211DOI: (10.1016/j.rmed.2006.11.003) Copyright © 2006 Elsevier Ltd Terms and Conditions