Disruptions in GI Cancers

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Presentation transcript:

Disruptions in GI Cancers

Pancreatic Cancer

CDKN2A/p16 inactivation

growth inhibition

Hedgehog

growth

paracrine signaling

Colorectal Cancer

HNPCC

(post-replication) & other DNA repair (post-replication) & other

PI3 Kinase

protein kinase C

Wnt

Adenomatous Polyposis Coli (APC)

½ life = 2 hrs ½ life = 20’ growth

apoptosis wnt

Bottom of Crypt Top of Crypt

Non-sense mutation Polyp

Chromosomal instability  Aneuploidy

Stomach Cancer

(e.g., H. pylori infection, bacteria/toxins from improperly-prepared food)

Interstitial cells of Cajal (SMCs)

Liver Cancer

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