Genistein: Its role in metabolic diseases and cancer

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Genistein: Its role in metabolic diseases and cancer Vidya Mukund, Dhruv Mukund, Vinay Sharma, Mastan Mannarapu, Afroz Alam Critical Reviews in Oncology / Hematology Volume 119, Pages 13-22 (November 2017) DOI: 10.1016/j.critrevonc.2017.09.004 Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 1 a. Multiple action genistein. Genistein inhibits the inflammation, insulin resistance, obesity and cancer. "↓" indicates the inducing effect and "⊥" indicates inhibitory effect. b. The generic structure of 17β-estradiol and Genistein. Critical Reviews in Oncology / Hematology 2017 119, 13-22DOI: (10.1016/j.critrevonc.2017.09.004) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 2 Genistein metabolic pathway and its major phase I and phase II metabolites in vivo. Critical Reviews in Oncology / Hematology 2017 119, 13-22DOI: (10.1016/j.critrevonc.2017.09.004) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 3 Molecular effects of genisten regulate metabolic and inflammatory signaling pathways. "↓" Indicates the inducing effect and "⊥" indicates inhibitory effect. Critical Reviews in Oncology / Hematology 2017 119, 13-22DOI: (10.1016/j.critrevonc.2017.09.004) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 4 Molecular effects of genisten on cancer inducing signaling pathways. "↓" indicates the inducing effect and "⊥" indicates inhibitory effect. Critical Reviews in Oncology / Hematology 2017 119, 13-22DOI: (10.1016/j.critrevonc.2017.09.004) Copyright © 2017 Elsevier B.V. Terms and Conditions