From: Methoxycarbonyl-etomidate:A Novel Rapidly Metabolized and Ultra–short-acting Etomidate Analogue that Does Not Produce Prolonged Adrenocortical Suppression.

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From: Methoxycarbonyl-etomidate:A Novel Rapidly Metabolized and Ultra–short-acting Etomidate Analogue that Does Not Produce Prolonged Adrenocortical Suppression Anesthes. 2009;111(2):240-249. doi:10.1097/ALN.0b013e3181ae63d1 Figure Legend: Fig. 5. Methoxycarbonyl-etomidate (MOC-etomidate) metabolite identification. ( A ) Mass spectrometry spectra of the major metabolite (main spectrum; m/z 289.2) and its major fragment ion (left inset spectrum; m/z 185.2). The metabolite produced a single major fragment ion at m/z 185.2 with a neutral loss of m/z 104, consistent with a conserved region of the parent compound. Subsequent mass spectrometry/mass spectrometry analysis of m/z 185.2 produced three major ions at m/z 94.96, 113.11, and 166.98. Right inset shows a possible fragmentation pathway supporting the proposed metabolite structure. ( B ) Metabolic pathway for methoxycarbonyl-etomidate upon incubation with human liver S9 fraction based on analysis of the metabolite’s major fragment ion. Date of download: 11/1/2017 Copyright © 2017 American Society of Anesthesiologists. All rights reserved.