Illustration of a pure ground-glass nodule which developed a solid component. a) June 2004; b) October 2004; c) June 2005; d) July 2007. Illustration of a pure ground-glass nodule which developed a solid component. a) June 2004; b) October 2004; c) June 2005; d) July 2007. The male trial participant was 57 years of age in 2004 and he was followed up until November 2012. The images show an axial cross-section with magnified axial (top), coronal (middle) and sagittal (bottom) reconstructions. The nodule was classified as a pure ground-glass nodule from the first three computed tomography images. The histological diagnosis was adenocarcinoma in situ. Ernst T. Scholten et al. Eur Respir J 2015;45:765-773 ©2015 by European Respiratory Society