Ground-Glass Centrilobular Nodules on Multidetector CT Scan

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Presentation transcript:

Ground-Glass Centrilobular Nodules on Multidetector CT Scan Myrna C.B. Godoy, MD, Daisuke Nonaka, MD, Joseph Lowy, MD, FCCP, Jane P. Ko, MD CHEST Volume 138, Issue 2, Pages 427-433 (August 2010) DOI: 10.1378/chest.09-1923 Copyright © 2010 The American College of Chest Physicians Terms and Conditions

Figure 1 Posteroanterior (A) and lateral (B) chest radiographs show a focal area of consolidation in the right lower lobe (arrows). A diffuse bilateral micronodular pattern is also present, but it is difficult to perceive in the chest radiographs. CHEST 2010 138, 427-433DOI: (10.1378/chest.09-1923) Copyright © 2010 The American College of Chest Physicians Terms and Conditions

Figure 2 High-resolution CT image at the level of the aortic arch shows bilateral ill-defined ground-glass nodules (A). One-millimeter CT images in lung and mediastinal windows at the level of the right inferior pulmonary vein show an area of rounded consolidation in the right lower lobe (B). CHEST 2010 138, 427-433DOI: (10.1378/chest.09-1923) Copyright © 2010 The American College of Chest Physicians Terms and Conditions

Figure 3 Transbronchial biopsy specimen. Area of interstitial fibrosis with chronic inflammatory infiltrates and multinucleated giant cells (hematoxylin-eosin, original magnification ×400) (A). Polarization of the same image shows large amounts of brightly birefringent plate-like talc crystals (B). CHEST 2010 138, 427-433DOI: (10.1378/chest.09-1923) Copyright © 2010 The American College of Chest Physicians Terms and Conditions

Figure 4 Follow-up high-resolution CT scan performed 2 months after antibiotic treatment shows persistent ill-defined ground-glass nodules in the upper lobes (A), and a marked reduction in the size of the area of consolidation in the right lower lobe (B), with development of a small central area of cavitation (thick arrow) and mild focal areas of decreased attenuation in the lower lobes, most likely representing air trapping (thin arrows). CHEST 2010 138, 427-433DOI: (10.1378/chest.09-1923) Copyright © 2010 The American College of Chest Physicians Terms and Conditions