Topiramate for the Treatment of Binge Eating Disorder Associated With Obesity: A Placebo-Controlled Study Susan L. McElroy, James I. Hudson, Julie A.

Slides:

Advertisements

Similar presentations

Silver linings for patients with depression? Michael Gross Current Biology Volume 24, Issue 18, Pages R851-R854 (September 2014) DOI: /j.cub

Advertisements

Stimulated Gene Expression Profiles as a Blood Marker of Major Depressive Disorder Sabine Spijker, Jeroen S. Van Zanten, Simone De Jong, Brenda W.J.H.

Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial Peter Nagele, Andreas Duma, Michael Kopec, Marie Anne Gebara, Alireza.

Date of download: 9/17/2016 From: Dose Response to Vitamin D Supplementation in Postmenopausal Women: A Randomized Trial Ann Intern Med. 2012;156(6):

Copyright © 2003 American Medical Association. All rights reserved.

Psychiatric Pharmacogenomics: How Close Are We?

Volume 26, Issue 2, Pages e2 (August 2017)

Copyright © 2010 American Medical Association. All rights reserved.

Volume 32, Pages (February 2016)

A Randomized, Placebo-Controlled Trial of OROS Methylphenidate in Adults with Attention-Deficit/Hyperactivity Disorder Joseph Biederman, Eric Mick, Craig.

Copyright © 2015 by the American Osteopathic Association.

T. Rain Carei, Ph. D. , Amber L. Fyfe-Johnson, N. D. , Cora C

Volume 104, Issue 11, Pages (November 2010)

Generalized Anxiety Disorder and Major Depressive Disorder in Pregnant and Postpartum Women: Maternal Quality of Life and Treatment Outcomes Shaila Misri,

Copyright © 2003 American Medical Association. All rights reserved.

Bipolar treatment efficacy

Wayne S. Dysinger, MD, MPH, James M. Pappas, MD, MBA

Oral Phenylephrine HCl for Nasal Congestion in Seasonal Allergic Rhinitis: A Randomized, Open-label, Placebo-controlled Study Eli O. Meltzer, MD, Paul.

An Evidence-based Guide for Obesity Treatment in Primary Care

The Inadmissibility of What We Eat in America and NHANES Dietary Data in Nutrition and Obesity Research and the Scientific Formulation of National Dietary.

An Evidence-based Guide for Obesity Treatment in Primary Care

Volume 135, Issue 4, Pages (October 2008)

Short-term placebo response in trials of patients with symptomatic osteoarthritis: differences between hip and knee S. Reiter-Niesert, M. Boers, J. Detert

Peripheral Arterial Disease: Diagnosis and Management

Efficacy and safety of naproxcinod in the treatment of patients with osteoarthritis of the knee: a 13-week prospective, randomized, multicenter study

Evaluation of the efficacy and safety of dienogest in the treatment of painful symptoms in patients with adenomyosis: a randomized, double-blind, multicenter,

Effect of a very-low-calorie diet on in vitro fertilization outcomes

Increased body-mass index in patients with narcolepsy

Randomized, multicenter, double-blind, placebo-controlled trial to evaluate the efficacy and safety of synthetic conjugated estrogens B for the treatment.

Body Composition and Heart Failure Prevalence and Prognosis: Getting to the Fat of the Matter in the “Obesity Paradox” Carl J. Lavie, MD, Richard V.

Association of the −243 A→G polymorphism of the glutamate decarboxylase 2 gene with obesity in girls with premature pubarche Selma Feldman Witchel, M.D.,

Telithromycin 800 mg once daily for seven to ten days is an effective and well-tolerated treatment for community-acquired pneumonia C. Carbon, S. Moola,

The influence of female and male body mass index on live births after assisted reproductive technology treatment: a nationwide register-based cohort study

Measures of body habitus are associated with lung function in adults with cystic fibrosis: A population-based study Doug L. Forrester, Alan J. Knox,

The Obesity Paradox, Weight Loss, and Coronary Disease

L.R. Peterson Clinical Microbiology and Infection

Evaluation of an ultra-low-dose oral contraceptive for dysmenorrhea: a placebo- controlled, double-blind, randomized trial Tasuku Harada, M.D., Mikio.

Iris G. Insogna, M. D. , Malinda S. Lee, M. D. , M. B. A. , Rebecca M

Body-mass index and mortality – Authors' reply

The Effect of a Telephone-Based Self-management Program Led by Nurses on Self- care Behavior, Biological Index for Cardiac Function, and Depression in.

David J. Hass, Colleen M. Brensinger, James D. Lewis, Gary R

Volume 91, Issue 2, Pages (February 2017)

Steven D. Targum, Christopher J. Catania

Safety of Celecoxib in Patients With Ulcerative Colitis in Remission: A Randomized, Placebo-Controlled, Pilot Study William J. Sandborn, William F. Stenson,

Severe Constipation Clinical Gastroenterology and Hepatology

The Molecular Pathology of Primary Immunodeficiencies

Current and emerging management options for Clostridium difficile infection: what is the role of fidaxomicin? O.A. Cornely Clinical Microbiology and.

Chronic Lymphocytic Leukemia: Diagnosis and Treatment

Patient-Initiated Second Opinions: Systematic Review of Characteristics and Impact on Diagnosis, Treatment, and Satisfaction Velma L. Payne, PhD, Hardeep.

International phase III trial of liprotamase efficacy and safety in pancreatic-insufficient cystic fibrosis patients Drucy Borowitz, Christopher Stevens,

Efficacy and Safety of a Magnesium Sulfate–Rich Natural Mineral Water for Patients With Functional Constipation Christophe Dupont, Alain Campagne, Florence.

Volume 63, Issue 2, Pages (February 2003)

Association between body mass index and risk of total knee replacement, the Singapore Chinese Health Study Y.-Y. Leung, J.C. Allen, M. Noviani, L.-W.

Efficacy and safety of duloxetine in Chinese patients with chronic pain due to osteoarthritis: a randomized, double-blind, placebo-controlled study G.

Volume 26, Issue 2, Pages e2 (August 2017)

Volume 148, Issue 3, Pages e4 (March 2015)

Volume 150, Issue 5, Pages (May 2016)

Scott I. Kahan, MD, MPH Mayo Clinic Proceedings

Volume 75, Issue 11, Pages (June 2009)

Comparing two low-energy diets for the treatment of knee osteoarthritis symptoms in obese patients: a pragmatic randomized clinical trial B.F. Riecke,

Safety and Efficacy of Bimatoprost Solution 0

Sanford Chodosh Clinical Microbiology and Infection

Randomized trial of efficacy and safety of dornase alfa delivered by eRapid nebulizer in cystic fibrosis patients Gregory S. Sawicki, Will Chou, Karina.

Does Morbid Obesity Worsen Outcomes After Esophagectomy?

The efficacy, safety and carry-over effect of diacerein in the treatment of painful knee osteoarthritis: a randomised, double-blind, NSAID-controlled.

Obesity does not impact implantation rates or pregnancy outcome in women attempting conception through oocyte donation Allison Styne-Gross, M.D., Karen.

Vasiliki A. Moragianni, M. D. , M. S. , Stephanie-Marie L. Jones, M. D

James B. Young, Hans-Hellmut Neumayer, Robert D. Gordon

Current evaluation of amenorrhea

Volume 82, Issue 11, Pages (December 2012)

Presentation transcript:

Topiramate for the Treatment of Binge Eating Disorder Associated With Obesity: A Placebo-Controlled Study Susan L. McElroy, James I. Hudson, Julie A. Capece, Karen Beyers, Alan C. Fisher, Norman R. Rosenthal Biological Psychiatry Volume 61, Issue 9, Pages 1039-1048 (May 2007) DOI: 10.1016/j.biopsych.2006.08.008 Copyright © 2007 Society of Biological Psychiatry Terms and Conditions

Figure 1 Population Flow Diagram. *Safety: all randomized patients for whom at least one post-baseline safety measure was available. †ITT: all randomized patients who received study medication and had at least one valid post-baseline efficacy evaluation. ‡mITT: all ITT patients excluding those with ≥ 1 major inclusion/exclusion violation (no diagnosis of binge eating disorder [BED]; did not have ≥ 3 binge days/week at baseline; had baseline body mass index [BMI] < 30 kg/m2; or Montgomery-Åsberg Depression Rating Scale [MADRS] > 24). §Completers: all randomized patients who completed all study visits up to and including visit 10 and exceeded 99 days of taking study medication. Biological Psychiatry 2007 61, 1039-1048DOI: (10.1016/j.biopsych.2006.08.008) Copyright © 2007 Society of Biological Psychiatry Terms and Conditions

Figure 2 The mean number of binge eating days/week. Biological Psychiatry 2007 61, 1039-1048DOI: (10.1016/j.biopsych.2006.08.008) Copyright © 2007 Society of Biological Psychiatry Terms and Conditions

Figure 3 The median number of binge eating days/week. Biological Psychiatry 2007 61, 1039-1048DOI: (10.1016/j.biopsych.2006.08.008) Copyright © 2007 Society of Biological Psychiatry Terms and Conditions

Figure 4 The mean number of binge eating episodes/week. Biological Psychiatry 2007 61, 1039-1048DOI: (10.1016/j.biopsych.2006.08.008) Copyright © 2007 Society of Biological Psychiatry Terms and Conditions

Figure 5 Body mass index. Biological Psychiatry 2007 61, 1039-1048DOI: (10.1016/j.biopsych.2006.08.008) Copyright © 2007 Society of Biological Psychiatry Terms and Conditions