Systemic opioid based analgesia

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Systemic opioid based analgesia Supplemental Figure C. Relationship between year of publication and incidence of perioperative death. Published and unpublished data (83 trials). Epidural analgesia Systemic opioid based analgesia 1980 1985 1990 1995 2000 2005 2010 1980 1985 1990 1995 2000 2005 2010 Tikuisis 2004 Tikuisis 2004 Jidéus 2001 Jidéus 2001 Year of publication Yeager 1987 5 10 15 20 25 30 5 10 15 20 25 30 Rate of death (%) Rate of death (%) Each symbol represents one trial. Vertical dotted lines show the average incidence of deaths with epidural analgesia (2.0%) and systemic opioid based analgesia (control) (3.2%). Outliers are identified. There was no significant trend in the odds of death over time with epidural analgesia (P=0.639) and systemic opioid based analgesia (P=0.202).