Uswa Shahzad, BHSc, Guangming Li, MD, Yaoguang Zhang, MD, Terrence M

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Presentation transcript:

Transmyocardial Revascularization Induces Mesenchymal Stem Cell Engraftment in Infarcted Hearts Uswa Shahzad, BHSc, Guangming Li, MD, Yaoguang Zhang, MD, Terrence M. Yau, MD, MS The Annals of Thoracic Surgery Volume 94, Issue 2, Pages 556-562 (August 2012) DOI: 10.1016/j.athoracsur.2012.03.048 Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Photomicrograph (200×) of (A) a section of a transmyocardial revascularization (TMR) heart and a (B) control heart. Nuclei of native cardiomyocytes are indicated with red arrows. Green fluorescence protein-expressing donor mesenchymal stem cells (MSCs) are stained brown and are indicated with green arrows. In panel (A), white arrows indicate a residual needle TMR tract. In the (A) TMR heart, donor MSCs are visible, clustered around the TMR needle tract. In the (B) control heart, donor MSCs are apparent but appear fewer in number and were not clustered together. The Annals of Thoracic Surgery 2012 94, 556-562DOI: (10.1016/j.athoracsur.2012.03.048) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Male donor mesenchymal stem cells (MSC) engraftment was markedly greater in transmyocardial revascularization (TMR) hearts than in control rats at both 3 days (panel A) and 1 week (panel B). Differences between groups were most pronounced at 3 days. The Annals of Thoracic Surgery 2012 94, 556-562DOI: (10.1016/j.athoracsur.2012.03.048) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Photomicrograph (200×) of a section of (A) a transmyocardial revascularization (TMR) heart and (B) a control heart stained brown for alpha-smooth muscle actin positive vessels. (A) The TMR hearts had greater arteriolar density than control hearts. The Annals of Thoracic Surgery 2012 94, 556-562DOI: (10.1016/j.athoracsur.2012.03.048) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions