Volume 131, Issue 5, Pages 1345-1352 (May 2007) Diagnostic Classification of Persistent Rhinitis and Its Relationship to Exhaled Nitric Oxide and Asthma  Rolla Giovanni , MD, FCCP, Guida Giuseppe , MD, Heffler Enrico , MD, Badiu Iuliana , MD, Bommarito Luisa , MD, De Stefani Antonella , MD, Usai Antonio , MD, Cosseddu Domenico , MD, Nebiolo Franco , MD, Bucca Caterina , MD  CHEST  Volume 131, Issue 5, Pages 1345-1352 (May 2007) DOI: 10.1378/chest.06-2618 Copyright © 2007 The American College of Chest Physicians Terms and Conditions

Figure 1 Clinical classification of patients depending on rhinitic symptoms. aIndicates when allergen sensitization and exposure are related to symptoms. bIndicates evaluated also by nasal cytology in order to identify patients affected by NARES. CHEST 2007 131, 1345-1352DOI: (10.1378/chest.06-2618) Copyright © 2007 The American College of Chest Physicians Terms and Conditions

Figure 2 Clinical classification of patients depending on airway involvement. aWhen PD20 was < 800 μg or FEV1 after bronchodilation testing with salbutamol was > 12% compared to the basal FEV1 value. bEosinophilic bronchitis if eosinophils > 3% of differential cell count. CHEST 2007 131, 1345-1352DOI: (10.1378/chest.06-2618) Copyright © 2007 The American College of Chest Physicians Terms and Conditions

Figure 3 Mean (95% CI) Feno values in patients with NAR, AR, and CRS depending on respiratory symptoms and diagnosis of asthma. *p = 0.015, comparing AR with asthma to AR with respiratory symptoms without asthma. †p < 0.05, comparing AR with asthma and AR with respiratory symptoms without asthma to AR with rhinitis only. ‡p < 0.01, comparing CRS with asthma and CRS with respiratory symptoms without asthma to CRS with rhinitis only. There were no significant differences in Feno values in all subgroups of NAR patients. Mean Feno values of AR, CRS (both p < 0.001), and NAR (p = 0.002) are significantly higher than healthy subjects (HS). CHEST 2007 131, 1345-1352DOI: (10.1378/chest.06-2618) Copyright © 2007 The American College of Chest Physicians Terms and Conditions